Recombinant Mouse 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Cyp27b1)

1. Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1alpha-Hydroxylase Expression in Vascular Smooth Muscle Cells PMID: 27074284
2. These results reveal that differential regulation of Cyp27b1 expression represents a mechanism whereby 1,25(OH)2D3 can fulfill separate functional roles, first in the kidney to control mineral homeostasis and second in extra-renal cells to regulate target genes linked to specific biological responses. PMID: 28808057
3. The data indicate that abnormal osteoclastogenesis due to the absence of CYP27B1 expression, consistent with the notion that endogenous metabolism of 25-hydroxyvitamin D optimizes osteoclastogenesis and ameliorates the resulting activity of mature osteoclasts. PMID: 26639637
4. The absence of 25-hydroxyvitamin D3-1alpha-hydroxylase potentiates the suppression of EAE in mice by ultraviolet light. PMID: 27108944
5. Cyp27b1(-/-) mice exhibited hypocalcemia, growth defects, and skeletogenesis dysfunction, similar to Vdr(-/-) mice, but do not display alopecia PMID: 28025137
6. Findings demonstrate that in-tumor CYP27B1 1-alpha-hydroxylase activity plays a crucial role in controlling early oncogene-mediated mammary carcinogenesis events, at least in part by modulating tumoral cell NF-kappaB p65 nuclear translocation. PMID: 27119753
7. the effect of 25-hydroxyvitamin D-1-alpha-hydroxylase on the atherosclerosis disease both in apolipoprotein (apo) E-/- mice and wild-type mice, was investigated. PMID: 28178628
8. P450C1 alpha deficiency results in abnormal calcium handling and cardiac dysfunction in mice with defective vitamin D signaling. PMID: 25268137
9. Throughout the male reproductive tract specific bands of CYP27B1 are determined. PMID: 23188491
10. observed a 3- to 10-fold increase in CYP27B1 mRNA abundance in the lung, spleen, aorta and testis of FGF-23 null/1alpha-Luc mice PMID: 24019880
11. Data show that the absence of either of the two key hydroxylases, vitamin D 25-hydroxylase (CYP2R1) or vitamin D 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)neither inhibits nor enhances the development of experimental autoimmune encephalomyelitis (EAE). PMID: 22592802
12. These results confirm the expression of vitamin D receptor and Cyp27b1 in vivo and suggest a potential role for vitamin D(3) in skeletal muscle regeneration following injury. PMID: 22648952
13. Bone formation parameters were increased significantly in all pups fed by dams on the rescue diet but were still lower in 1alpha(OH)ase(-/-) pups than in 1alpha(OH)ase(+/-) pups. PMID: 21791625
14. 1alpha-hydroxylase may have a role in enhanced radiosensitivity PMID: 21343672
15. regulation of bone CYP27B1 is unique from that in the kidney, and may play an important role in bone formation PMID: 20236619
16. study shows CYP27B1 can hydroxylate 25-hydroxyvitamin D2 & 25-hydroxyvitamin D3 associated with phospholipid membranes; low activity found at higher membrane levels of 25-hydroxyvitamin D; substrate inhibition may contribute to enzyme activity regulation PMID: 20193763
17. both 1alphaOHase gene ablation and Pi supplementation inhibit renal calcification in Npt2-/- mice and that 1,25(OH)2D is essential for the development of hypercalciuria and nephrocalcinosis in the mutant strain. PMID: 14656762
18. leptin suppresses renal gene overexpression for 1 alpha-hydroxylase and 24-hydroxylase and corrects increased serum concentrations of calcium and phosphate in ob/ob mice. PMID: 14657008
19. 1 alpha-OHase knockout mice fed a normal Ca2+ diet developed severe hypocalcemia, rickets and died with an average life span of 12 +/- 2 weeks PMID: 14717923
20. 25OHD 1OHase essential for normal epidermal differentiation, most likely by producing vitamin D metabolite, 1,25(OH)(2)D, responsible for inducing proteins regulating calcium levels in epidermis critical for generation and maintenance of barrier. PMID: 15102089
21. 5' flanking region of the gene directs expression to the proximal convoluted tubules of the kidney PMID: 15691891
22. study of substrate recognition of CYP27B1 PMID: 15972816
23. CYP27B1 null mice with LacZreporter gene display no 25-hydroxyvitamin D3-1alpha-hydroxylase promoter activity in the skin. PMID: 16371465
24. These results suggest that adrenodoxin functions as an effector for the oxygen transfer reaction in addition to being an electron donor for CYP27B1. PMID: 16584176
25. confirm a crucial role for STAT1alpha as well as for C/EBPbeta in the regulation of 1alpha-hydroxylase in monocytes PMID: 17267208
26. leptin attenuates renal 1alpha-hydroxylase gene expression through ObRb. Furthermore, leptin appears to act indirectly on renal proximal tubules to regulate 1alpha-hydroxylase gene expression. PMID: 17400175
27. FGF-23 directly regulates renal 1alpha-hydroxylase gene expression via activation of the ERK1/2 signaling pathway. PMID: 17699549
28. Neither high dietary Ca nor high dietary vitamin D3 is sufficient to fully recover the phenotype of CYP27B1 KO mice. PMID: 18029472
29. Results demonstrate that the proximal 1.5kb 5' flanking region of the CYP27B1 gene directs the expression of CYP27B1 in a number of known and novel tissues in a specific manner. PMID: 18313834
30. Lack of Cyp27b1 exacerbates disease in mouse model, suggesting that similar effects may occur with vitamin D deficiency PMID: 18535110
31. 1alpha-hydroxylase is expressed in adipose tissue and is functional in cultured adipocytes. PMID: 18840526
32. Results from genetic manipulation of expression of Cyp27b1 in chondrocytes support direct role for locally synthesized 1,25(OH)2D3, acting through the vitamin D receptor, in vascular invasion & osteoclastogenesis during endochondral bone development. PMID: 19477943

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KEGG: mmu:13115

STRING: 10090.ENSMUSP00000130005

UniGene: Mm.6216