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  4. Recombinant Mouse 15-hydroxyprostaglandin dehydrogenase [NAD (+)] (Hpgd)

Recombinant Mouse 15-hydroxyprostaglandin dehydrogenase [NAD (+)] (Hpgd)

  • 中文名称：
    小鼠Hpgd重组蛋白
  • 货号：
    CSB-YP819739MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hpgd重组蛋白
  • 货号：
    CSB-EP819739MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hpgd重组蛋白
  • 货号：
    CSB-EP819739MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hpgd重组蛋白
  • 货号：
    CSB-BP819739MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hpgd重组蛋白
  • 货号：
    CSB-MP819739MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hpgd
  • Uniprot No.：
    Q8VCC1
  • 别名：
    Hpgd; Pgdh1; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-PGDH; EC 1.1.1.141; Prostaglandin dehydrogenase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-269
  • 氨基酸序列
    MHVNGKVALV TGAAQGIGKA FAEALLLHGA KVALVDWNLE AGVKCKAALD EQFEPQKTLF VQCDVADQKQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EQTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV YCASKHGIIG FTRSAAMAAN LMKSGVRLNV ICPGFVDTPI LESIEKEENM GQYIEYKDQI KAMMKFYGVL HPSTIANGLI NLIEDDALNG AIMKITASKG IHFQDYDISP LLVKAPLTS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites. Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE). Has hydroxylated docosahexaenoic acid metabolites as substrates. Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions.
  • 基因功能参考文献：
    1. down-regulation of 15-hydroxy prostaglandin dehydrogenase is crucial for Prostaglandin E2-induced cervical ripening and preterm birth. PMID: 28716915
    2. 15-PGDH prevents lipopolysaccharide-induced acute liver injury in mice. PMID: 28423012
    3. the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in Amyotrophic lateral sclerosis model mice at three different disease stages, was investigated. PMID: 27140190
    4. 15-PGDH is downregulated in human hepatoma cells with a high COX-2 expression, in chemical and genetic murine models of hepatocellular carcinoma (HCC) and in human HCC biopsies. PMID: 23954207
    5. Data from a mouse model suggest that expression of Hpgd protein in uterus is down-regulated in lipopolysaccharide/infection-induced embryo loss. PMID: 22843771
    6. prostaglandin E synthase (cPGES/p23) acts as a regulatory factor for expression of a prostaglandin E2 -inactivating enzyme,15-hydroxyprostaglandin dehydrogenase ( 15-PGDH). PMID: 21334450
    7. I. sinclarii is effective in lowering blood glucose due to the upregulation of glucokinase (Gk-rs1) and downregulation of hydroxyprostaglandin dehydrogenase. PMID: 20954077
    8. OAT-PG is proposed to be involved in the local PGE(2) clearance and metabolism for the inactivation of prostaglandin signals in the kidney cortex. PMID: 20448048
    9. novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression PMID: 15542609
    10. 15-Hydroxyprostaglandin dehydrogenase has a role in suppressing colon tumorigenesis PMID: 16880406
    11. The intrarenal distribution of 15-PGDH and its interactions with COX-2 suggest that differential regulation of COX-2 and 15-PGDH plays a role in determining levels of prostaglandins involved in regulation of salt, volume, and blood pressure homeostasis. PMID: 18057186

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    Expressed in proximal convoluted tubules of the kidney, where it colocalizes with the prostaglandin transporter SLC22A22 (at protein level). Expressed in lung, intestine, stomach and liver.
  • 数据库链接：

    KEGG: mmu:15446

    STRING: 10090.ENSMUSP00000034026

    UniGene: Mm.18832

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