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  4. Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (Plcd4), partial

Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (Plcd4), partial

  • 中文名称：
    小鼠Plcd4重组蛋白
  • 货号：
    CSB-YP811707MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Plcd4重组蛋白
  • 货号：
    CSB-EP811707MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Plcd4重组蛋白
  • 货号：
    CSB-EP811707MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Plcd4重组蛋白
  • 货号：
    CSB-BP811707MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Plcd4重组蛋白
  • 货号：
    CSB-MP811707MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Plcd4
  • Uniprot No.：
    Q8K3R3
  • 别名：
    Plcd4; Plcd; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; EC 3.1.4.11; Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
  • 基因功能参考文献：
    1. We identify PLCdelta4 as a PLC isoform important in the regulation of TRPM8 both at the cellular level and in vivo PMID: 27062607
    2. PLCd4 has a role in the zona pellucida-induced acrosome reaction in mice PMID: 12791385
    3. PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) and the PH domain of PLCdelta(4) does not act as a localization signal PMID: 15037625
    4. It is concluded that PLC delta4 regulates the liver regeneration in cooperation with nuclear PKC alpha and epsilon PMID: 16998201
    5. PLCd4 is required for the acrosome reaction in fertilization. PMID: 18177742

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  • 亚细胞定位：
    Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum.
  • 数据库链接：

    KEGG: mmu:18802

    STRING: 10090.ENSMUSP00000027362

    UniGene: Mm.290731

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