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  4. Recombinant Nipah virus Matrix protein (M)

Recombinant Nipah virus Matrix protein (M)

  • 中文名称：
    Recombinant Nipah virus Matrix protein(M)
  • 货号：
    CSB-YP867446NDT
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Nipah virus Matrix protein(M)
  • 货号：
    CSB-EP867446NDT
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Nipah virus Matrix protein(M)
  • 货号：
    CSB-EP867446NDT-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Nipah virus Matrix protein(M)
  • 货号：
    CSB-BP867446NDT
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Nipah virus Matrix protein(M)
  • 货号：
    CSB-MP867446NDT
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    M
  • Uniprot No.：
    Q9IK90
  • 别名：
    M; Matrix protein; Protein M
  • 种属：
    Nipah virus
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-352
  • 氨基酸序列
    MEPDIKSISS ESMEGVSDFS PSSWEHGGYL DKVEPEIDEN GSMIPKYKIY TPGANERKYN NYMYLICYGF VEDVERTPET GKRKKIRTIA AYPLGVGKSA SHPQDLLEEL CSLKVTVRRT AGSTEKIVFG SSGPLNHLVP WKKVLTSGSI FNAVKVCRNV DQIQLDKHQA LRIFFLSITK LNDSGIYMIP RTMLEFRRNN AIAFNLLVYL KIDADLSKMG IQGSLDKDGF KVASFMLHLG NFVRRAGKYY SVDYCRRKID RMKLQFSLGS IGGLSLHIKI NGVISKRLFA QMGFQKNLCF SLMDINPWLN RLTWNNSCEI SRVAAVLQPS IPREFMIYDD VFIDNTGRIL KG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a crucial role in virion assembly and budding. Forms a shell at the inner face of the plasma membrane. Transits through the host nucleus before gaining the functional ability to localize and bud from the plasma membrane. Mediates together with fusion protein the incorporation of the glycoprotein to the viral particles. Participates also in the inhibition of the host interferon type I antiviral response by interacting with and thereby inhibiting host TRIM6.
  • 基因功能参考文献：
    1. Live NiV infection, but not a recombinant NiV lacking the M protein, reduced the levels of endogenous TRIM6 protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6, IKKepsilon and unanchored polyubiquitin chains. PMID: 27622505
    2. These data demonstrate that the M protein is not absolutely required for the production of cell-free virus but is necessary for proper assembly and release of stable infectious virus particles. PMID: 26676785
    3. Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization. PMID: 17005661
    4. The results indicate that NiV M, F, and G each possess some ability to bud from expressing cells, and that co-expression of these viral proteins results in a more organized budding process with M playing a central role. PMID: 17204159
    5. The YPLGVG motif in the M protein plays an important role in Nipah virus budding. PMID: 19000317

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  • 亚细胞定位：
    Virion. Host cytoplasm. Host cell membrane. Host nucleus.
  • 蛋白家族：
    Morbillivirus/respirovirus/rubulavirus M protein family
  • 数据库链接：

    KEGG: vg:920953

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