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  4. Recombinant Listeria monocytogenes serovar 1/2a Internalin-A (inlA) (S192N,Y369S), partial

Recombinant Listeria monocytogenes serovar 1/2a Internalin-A (inlA) (S192N,Y369S), partial

In Stock
  • 中文名称：
    单核增生李斯特菌血清1/2ainlA重组蛋白
  • 货号：
    CSB-EP338647LPY(M)
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    inlA
  • Uniprot No.：
    P0DJM0
  • 种属：
    Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    48.9 kDa
  • 表达区域：
    32-414aa(S192N,Y369S)
  • 氨基酸序列
    NAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTLQADRLGIKSIDGVEYLNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITPLANLTNLTGLTLFNNQITDIDPLKNLTNLNRLELSSNTISDISALSGLTSLQQLNFGNQVTDLKPLANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQISDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTNLELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFSNNKVSDVSSLANLTNINWLSAGHNQISDLTPLANLTRITQLGLND
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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inlA Proteins

靶点详情

  • 功能：
    Mediates the entry of L.monocytogenes into host intestinal epithelial cells; transformation with inlA alone allows L.innocua (a non-invasive species) to be taken up by host cells. Binds to human receptor cadherin-1 (E-cadherin, CDH1); the chicken homolog of cadherin-1 but not cadherin-2 function as receptors. Mouse cadherin-1 is not a receptor, however mutating a single surface-exposed residue (Glu-172 to Pro in mouse) allows cadherin-1 to act as a receptor for InlA.
  • 基因功能参考文献：
    1. Deletion of either one or both proteins leads to a similarly decreased invasion, suggesting an interdependent function of InlA and InlB during invasion of choroid plexus epithelial cells. PMID: 23376167
    2. About 40% of Listeria monocytogenes isolates (three subtypes) were found to potentially present attenuated virulence because of the presence of mutations in the prfA and inlA genes PMID: 23317868
    3. A novel single amino acid change in inlA enhanced virulence by the oral route in the murine model. PMID: 21144051
    4. Listeria monocytogenes internalin interacts with E-cadherin [review] PMID: 20066101
    5. L. monocytogenes subtypes are common among U.S. food isolates but rare among human listeriosis isolates carry inlA mutations. PMID: 16332872
    6. Differential expression levels of inlA and inlB possibly play a role in the virulence capacities of Listeria monocytogenes strains. PMID: 16751490
    7. Sequence analyses of inlA among L. monocytogenes isolated from ready-to-eat seafood revealed that only one out of 59 isolates had a nonsense-mutated inlA which indicated that these strains could be fully virulent based on the size of this protein. PMID: 17566579
    8. the essential and interdependent roles of InlA and InlB in fetoplacental listeriosis PMID: 18806773
    9. analysis of the internalin multigene family in Listeria PMID: 18840511
    10. truncated and/or proteolytically cleaved InlA are likely involved in the biofilm enhancement. PMID: 19309566

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  • 亚细胞定位：
    Secreted, cell wall; Peptidoglycan-anchor. Secreted.
  • 数据库链接：

    KEGG: lmo:lmo0433

    STRING: 169963.lmo0433

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