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  4. Recombinant Hypoxia-inducible factor 1 (hif-1), partial

Recombinant Hypoxia-inducible factor 1 (hif-1), partial

  • 中文名称：
    秀丽隐杆线虫hif-1重组蛋白
  • 货号：
    CSB-YP515301CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫hif-1重组蛋白
  • 货号：
    CSB-EP515301CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫hif-1重组蛋白
  • 货号：
    CSB-EP515301CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫hif-1重组蛋白
  • 货号：
    CSB-BP515301CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫hif-1重组蛋白
  • 货号：
    CSB-MP515301CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    hif-1
  • Uniprot No.：
    G5EGD2
  • 别名：
    hif-1; F38A6.3; Hypoxia-inducible factor 1; Hypoxia-induced factor 1
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size. Involved in mediating susceptibility to enteropathogenic E.coli. Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureus infection. Required for aha-1 nuclear localization. Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression. Role in life span extension is dependent of temperature. Not required for survival in anoxic conditions. Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3. May be involved in manganese homeostasis by repressing divalent metal transporter smf-3.
  • 基因功能参考文献：
    1. Our results suggest that these detoxification pathways are mediated by the hypoxia inducible factor HIF-1. Finally, we show that sulfide resistance varies among wild C. elegans and other nematode species, suggesting that tolerance to sulfide was naturally selected in certain habitats. PMID: 28179109
    2. blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function. PMID: 27618966
    3. HIF-1-mediated activation of 5-HT signalling promotes axon regeneration by activating both the RhoA and cAMP pathways. PMID: 26790951
    4. AMPK and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS PMID: 25288734
    5. HIF can function either as a gene-specific inducer or repressor of host defense, providing a molecular mechanism by which HIF can have apparently opposing roles in defense and inflammation. PMID: 22792069
    6. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae. PMID: 22921415
    7. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage. PMID: 22194696
    8. Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner. PMID: 21241450
    9. Data show that that reactive oxygen species (ROS) are increased in respiration mutants and that mild increases in ROS can stimulate HIF-1 to activate gene expression and promote longevity. PMID: 21093262
    10. transgerminal neuroectodermal conversion of hMSCs into NSC-like cells is accompanied by extensive changes of their global gene expression profile, which might be controlled in part by transcription factor networks related to HIF-1 and miR-124a PMID: 20599952
    11. HIF-1 upregulation is both an evolutionarily conserved and a necessary component of heat acclimation. PMID: 12686697
    12. In Caenorhabditis elegans the product of the hif-1 gene plays a crucial role in heat adaptation. PMID: 12824472
    13. studies identified hypoxia-regulated gene expression changes requiring hypoxia-inducible transcription factor (HIF-1) function in response to low oxygen levels PMID: 15781453
    14. Hypoxia caused specific axon pathfinding and neuronal migration defects in C. elegans that result from the stabilization of the transcription factor HIF-1 (hypoxia-inducible factor 1) in neurons and muscle. PMID: 18587389
    15. loss of VHL-1 increased life span; deletion of HIF-1 was epistatic to VHL-1, indicating HIF-1 acts downstream of VHL-1 to modulate aging; VHL-1 & HIF-1 control longevity by a mechanism distinct from dietary restriction & insulin-like signaling PMID: 19372390
    16. HIF-1 deficiency results in extended lifespan, which overlaps with that by inhibition of the RSKS-1/S6 kinase, a key component of the TOR pathway. PMID: 19461873
    17. C. elegans are protected from lethal hypoxia by an embryonic diapause, and neuronal HIF-1 activity in the adult dictates the O(2) tension at which the diapause is engaged. PMID: 19576771
    18. data establish HIF-1 as one of the key stress-responsive transcription factors that modulate longevity in C. elegans and advance our understanding of the regulatory networks that link oxygen homeostasis and aging PMID: 19633713

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in all somatic cells.
  • 数据库链接：

    KEGG: cel:CELE_F38A6.3

    STRING: 6239.F38A6.3b

    UniGene: Cel.17085

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