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  4. Recombinant Human von Willebrand factor C and EGF domain-containing protein (VWCE), partial

Recombinant Human von Willebrand factor C and EGF domain-containing protein (VWCE), partial

  • 中文名称：
    人VWCE重组蛋白
  • 货号：
    CSB-YP856918HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人VWCE重组蛋白
  • 货号：
    CSB-EP856918HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人VWCE重组蛋白
  • 货号：
    CSB-EP856918HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人VWCE重组蛋白
  • 货号：
    CSB-BP856918HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人VWCE重组蛋白
  • 货号：
    CSB-MP856918HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    VWCE
  • Uniprot No.：
    Q96DN2
  • 别名：
    HBV X protein up-regulated gene 11 protein; HBxAg up-regulated gene 11 protein; von Willebrand factor C and EGF domain-containing protein; VWCE; VWCE_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
  • 基因功能参考文献：
    1. silencing of URG11 altered the expression levels of cell cycleassociated genes, epithelialmesenchymal transitionassociated genes, and RhoA and ROCK1 protein levels. Thus, the results of the present study suggest that URG11 may be a potential therapeutic target, which may be important to inhibit the development and progression of prostatic hyperplasia. PMID: 29749520
    2. the study reported here provided evidence that URG11 downregulation suppresses proliferation, invasion, and beta-catenin expression in NSCLC cells. Our study uncovered a novel role for URG11 in NSCLC progression; thus, URG11 may be a novel potential therapeutic target for NSCLC. PMID: 27458101
    3. URG11 could promote hepatocellular carcinoma (HCC) cell growth and proliferation. It might play an important role in HCC development. PMID: 26522362
    4. Up-regulation of URG11 in pancreatic cancer leads to enhancing epithelial-mesenchymal transition-driven invasion and thus lead to poor prognosis. PMID: 24930007
    5. Increased expression of both URG11 was associated with decrease renal function in IgA nephropathy. PMID: 23828164
    6. Data suggest that URG11 contributes to gastric cancer growth and metastasis at least partially through activation of beta-catenin signalling pathway. PMID: 19413886
    7. URG11 mediates hypoxia-induced epithelial-to-mesenchymal transition through the suppression of E-cadherin and the activation of the beta-catenin/T-cell factor pathway. PMID: 19900406
    8. beta-catenin is activated by HBxAg, in part, through the upregulated expression of the HBxAg effector URG11; URG11 stimulates the beta-catenin promoter and hepatocellular growth and survival PMID: 16496348

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed in liver.
  • 数据库链接：

    HGNC: 26487

    OMIM: 611115

    KEGG: hsa:220001

    STRING: 9606.ENSP00000334186

    UniGene: Hs.60640

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