Recombinant Human tRNA (adenine (58)-N (1))-methyltransferase catalytic subunit TRMT61A (TRMT61A)

^{In Stock}

中文名称：

人TRMT61A重组蛋白
货号：

CSB-EP836214HU
规格：

￥1836
图片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

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纯度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

TRMT61A
Uniprot No.：

Q96FX7
别名：

(adenine(58)(1)(mRNA methyladenosine-N(1)(tRNA(m1A58)(tRNA(m1A58)
种属：

Homo sapiens (Human)
蛋白长度：

Full Length
来源：

E.coli
分子量：

35.5 kDa
表达区域：

1-289aa
氨基酸序列

MSFVAYEELIKEGDTAILSLGHGAMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVTCGRGGWVYVLHPTPELWTLNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQEHRVGRWVTVRTQDVCRSGFGVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGFSELSTLEVLPQVYNVRTVSLPPPDLGTGTDGPAGSDTSPFRSGTPMKEAVGHTGYLTFATKTPG
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白标签：

N-terminal 6xHis-tagged
产品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

3-7 business days
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

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功能：

Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries.
基因功能参考文献：
1. we suggest that PKCA tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development. PMID: 26234676
2. The TRM61 heterotetramer is the only active species, both subunits are required for orientating tRNA for catalysis at Trm61. PMID: 26470919
亚细胞定位：

Nucleus.
蛋白家族：

Class I-like SAM-binding methyltransferase superfamily, TRM61 family
数据库链接：

HGNC: 23790

KEGG: hsa:115708

STRING: 9606.ENSP00000374399

UniGene: Hs.525610

Recombinant Human tRNA (adenine (58)-N (1))-methyltransferase catalytic subunit TRMT61A (TRMT61A)

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