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  4. Recombinant Human adenovirus C serotype 2 Penton protein (PIII), partial

Recombinant Human adenovirus C serotype 2 Penton protein (PIII), partial

  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Penton protein(PIII) ,partial
  • 货号：
    CSB-YP365895HIK
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Penton protein(PIII) ,partial
  • 货号：
    CSB-EP365895HIK
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Penton protein(PIII) ,partial
  • 货号：
    CSB-EP365895HIK-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Penton protein(PIII) ,partial
  • 货号：
    CSB-BP365895HIK
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Penton protein(PIII) ,partial
  • 货号：
    CSB-MP365895HIK
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    L2
  • Uniprot No.：
    P03276
  • 别名：
    L2; Penton protein; CP-P; Penton base protein; Protein III
  • 种属：
    Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.
  • 基因功能参考文献：
    1. Ad major core protein VII is not required to condense viral DNA within the capsid, but rather plays an unexpected role during virus maturation and the early stages of infection. PMID: 28628648
    2. Authors show that the amphipathic helix of protein VI contributes to capsid stability by preventing premature disassembly and deployment of pentons and protein VI. PMID: 25473051
    3. B23 regulated the association of viral core proteins and cellular histones with the virus genome. PMID: 22337638
    4. results show that the early detachment of GFP-pV occurs before or shortly after virus penetration into the cytosol, while the second step takes place at the nuclear membrane, presumably the nuclear pore complex PMID: 21047958
  • 亚细胞定位：
    Virion. Host nucleus.
  • 蛋白家族：
    Adenoviridae penton family
  • 数据库链接：

    KEGG: vg:2652996

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