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  4. Recombinant Human Zinc finger protein ZFPM1 (ZFPM1), partial

Recombinant Human Zinc finger protein ZFPM1 (ZFPM1), partial

  • 中文名称：
    人ZFPM1重组蛋白
  • 货号：
    CSB-YP809003HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZFPM1重组蛋白
  • 货号：
    CSB-EP809003HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZFPM1重组蛋白
  • 货号：
    CSB-EP809003HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZFPM1重组蛋白
  • 货号：
    CSB-BP809003HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZFPM1重组蛋白
  • 货号：
    CSB-MP809003HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZFPM1
  • Uniprot No.：
    Q8IX07
  • 别名：
    FOG-1; FOG1_HUMAN; Friend of GATA 1; Friend of GATA protein 1; Friend of GATA1; ZFPM1; Zinc finger protein; Zinc finger protein 89A; Zinc finger protein multitype 1; Zinc finger protein ZFPM1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
  • 基因功能参考文献：
    1. Forced FOG1 protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 protein, but repressed that of transcription factor PU.1. PMID: 28216155
    2. GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor. PMID: 26503584
    3. FOG1 is a member of the PR domain containing, zinc finger protein family of transcriptional regulators. PMID: 25162672
    4. Our results reveal that the protein structure does not affect ligand binding, and the top three TCM candidates Bittersweet alkaloid II, Eicosandioic acid, and Perivine might resolve the instability of the RbAp48-FOG1 complex PMID: 25165715
    5. ZFPM1 that facilitates human Th1 differentiation via the downregulation of IL-4 is a potential target for the treatment of allergic diseases. PMID: 21646796
    6. Anagrelide suppresses megakaryocytopoiesis by reducing the expression levels of GATA-1 and FOG-1 via a PDEIII-independent mechanism that is differentiation context-specific and does not involve inhibition of MPL-mediated early signal transduction events PMID: 20586925
    7. The FOG-1 peptide contacts a negatively charged binding pocket on top of the RbAp48 beta-propeller that is distinct from the binding surface used by RpAp48 to contact histone H4 PMID: 21047798
    8. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affects DNA binding but does not affect FOG-1 interaction.(FOG1, cofactor of GATA1) PMID: 12200364
    9. Erythroid and megakaryocytic lineage differentiation and maturation are regulated via cooperation between transcription factor GATA1 and its essential cofactor FOG1. It depends on the binding of FOG1 to the N-terminalfinger of GATA1. PMID: 12483298
    10. 3D structure of a complex comprising the interaction domains of FOG1 and GATA1 reveals how zinc fingers can act as protein recognition motifs and provides a molecular explanation for how GATA-1 mutations contribute to distinct, related genetic diseases. PMID: 15644435
    11. Megakaryocytes from idiopathic myelofibrosis patients have reduced GATA-1 content, possibly contributing to disease pathogenesis as in the GATA-1(low) mice. PMID: 16127162
    12. Data verified the function of Zfpm-1 during erythropoietic differentiation. PMID: 17207461
    13. FOG-1 inhibits mast-cell differentiation in a differentiation stage-dependent manner, and its effects are produced via different molecular mechanisms. PMID: 18063754
    14. two novel mechanisms for the regulation of GATA1 interaction with FOG1-dependent protein complexes through the production of two translational isoforms with differential interaction profiles and independent nuclear localization controls. PMID: 19654328

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    FOG (Friend of GATA) family
  • 组织特异性：
    Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.
  • 数据库链接：

    HGNC: 19762

    OMIM: 601950

    KEGG: hsa:161882

    STRING: 9606.ENSP00000326630

    UniGene: Hs.632218

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