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  4. Recombinant Human Zinc finger protein 521 (ZNF521), partial

Recombinant Human Zinc finger protein 521 (ZNF521), partial

  • 中文名称：
    人ZNF521重组蛋白
  • 货号：
    CSB-YP026811HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZNF521重组蛋白
  • 货号：
    CSB-EP026811HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZNF521重组蛋白
  • 货号：
    CSB-EP026811HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZNF521重组蛋白
  • 货号：
    CSB-BP026811HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZNF521重组蛋白
  • 货号：
    CSB-MP026811HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNF521
  • Uniprot No.：
    Q96K83
  • 别名：
    B930086A16Rik; DKFZp564D0764; Early hematopoietic zinc finger; Early hematopoietic zinc finger protein; EHZF; Evi3; LYST-interacting protein 3; MGC142182; MGC142208; Zfp521; Zinc finger protein 521; ZN521_HUMAN; Znf521
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
  • 基因功能参考文献：
    1. Performance metrics were used to select SNPs in stage 1, which were then genotyped to another dataset (stage 2). Four SNPs (CPXM2 rs2362967, APOC1 rs4420638, ZNF521 rs7230380, and rs12965520) were identified for LOAD by both traditional P-values (without correcting for multiple tests) and performance metrics. PMID: 27805002
    2. IHC based post-Ki67 levels may have distinct predictive power compared with the naive IHC Ki67. PMID: 28412727
    3. knockdown of ZNF521 reduced proliferation in human leukemia cell lines possessing MLL-AF9 translocations PMID: 28615219
    4. Data show that zinc finger protein 521 (ZNF521) can function as a repressor of osteoblastic differentiation of bone marrow mesenchymal stem cells (bmMSCs). PMID: 26008984
    5. Newly discovered ZNF521-molecular partners of potentially relevant functional role, such as ZNF423, Spt16, Spt5, were discovered and validated by Western blotting. PMID: 25774781
    6. Data strongly support the notion that ZNF521, through the recruitment of the NuRD complex, contributes to the clonogenic growth, migration and tumorigenicity of medulloblastoma cells. PMID: 23907569
    7. Data show that ZNF521 can antagonize B-cell development and support the notion that it may contribute to conserve the multipotency of primitive lympho-myeloid progenitors by preventing or delaying their EBF1-driven commitment toward the B-cell lineage. PMID: 21593590
    8. Zinc finger protein 521, a new player in bone formation. PMID: 20392215
    9. EHZF is likely to play a relevant role in the control of human hematopoiesis and might be implicated in the development of hematopoietic malignancies. PMID: 14630787
    10. A review of possible roles for ZNF521 in development, stem cell regulation and oncogenesis. PMID: 17543573
    11. ZNF521 modulates erythroid cell differentiation through direct binding with GATA-1. PMID: 19049973
    12. Enhanced resistance of target cells to NK cell-mediated cytotoxicity was induced by enforced expression of EHZF in the cervical carcinoma cell line HeLa and in the B lymphoblastoid cell line IM9 PMID: 19342626

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  • 相关疾病：
    A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abund
  • 数据库链接：

    HGNC: 24605

    OMIM: 610974

    KEGG: hsa:25925

    STRING: 9606.ENSP00000354794

    UniGene: Hs.116935

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