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  4. Recombinant Human Zinc finger protein 217 (ZNF217), partial

Recombinant Human Zinc finger protein 217 (ZNF217), partial

  • 中文名称：
    人ZNF217重组蛋白
  • 货号：
    CSB-YP026586HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZNF217重组蛋白
  • 货号：
    CSB-EP026586HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZNF217重组蛋白
  • 货号：
    CSB-EP026586HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZNF217重组蛋白
  • 货号：
    CSB-BP026586HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZNF217重组蛋白
  • 货号：
    CSB-MP026586HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNF217
  • Uniprot No.：
    O75362
  • 别名：
    ZABC 1; ZABC1; Zinc finger protein 217; ZN 217; ZN217; ZN217_HUMAN; ZNF 217; ZNF217
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.
  • 基因功能参考文献：
    1. this study underscored that elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin -conducted iron egress PMID: 27768596
    2. this paper shows that hypoxia-inducible factors regulate pluripotency factor expression by ZNF217-mediated modulation of RNA methylation in breast cancer cells PMID: 27590511
    3. ZNF217 overexpression is associated with neoplasms. PMID: 27007163
    4. GATA3-driven expression of miR-503 inhibits prostate cancer progression by repressing ZNF217 expression. PMID: 27267060
    5. ZNF217 regulates N6-methyladenosine mRNA deposition in embryonic stem cells thus contributing to tumorigenesis by dysregulating gene expression programs. PMID: 27519282
    6. The report shows that the ZNF217 oncogene is a crucial mediator and indicator of bone metastasis from breast cancer. PMID: 28207159
    7. findings indicate that lncRNA-ATB governs the autocrine secretion of TGF-beta2 in KFs, at least in part, by downregulating the expression level of ZNF217 via miR-200c, suggesting a signaling axis consisting of lncRNA-ATB/miR-200c/ZNF217/TGF-beta2 PMID: 27090737
    8. Review: highlight the downstream molecular targets and signaling pathways of ZNF217 in tumor cells. PMID: 26431164
    9. High expression of ZNF217 is associated with enhanced cell migration and invasion in colorectal carcinoma. PMID: 25824781
    10. Two polymorphisms in ZNF217 in Mexican patients with colorectal cancer, were studied. PMID: 25729968
    11. ZNF217 has an oncogenic role in colorectal cancer and is regulated by miR-203. PMID: 25621839
    12. we conclude that ZNF217 may contribute to ovarian cancer invasion and metastasis, and associated with worse clinical outcomes. PMID: 25031722
    13. Synergic effects of loss of ARID1A and PI3K-Akt pathway activation as well as ZNF217 amplification may be related to the development of ovarian clear cell carcinoma. PMID: 24336158
    14. ERalpha expression highly correlates with ZNF217 in lysates from breast tumors. PMID: 24962896
    15. ZNF217 expression seems to be a novel prognostic biomarker in gastric cancer. PMID: 25202062
    16. Study investigated nested regulatory circuits of miR-200c/ZEB1 and miR-200c/ZNF217/TGF-beta/ZEB1 in synergistically promoting trastuzumab resistance and metastasis of breast cancer cells. PMID: 24615544
    17. New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. PMID: 23436653
    18. downregulation of miR-24ZNF17 in prostate cancer (PCa) corresponds to an upregulation of ZNF217; ZNF217 could be identified as an oncogene because it is overexpressed in prostate cancer (PCa) and affects the growth of PCa cell lines PMID: 22815235
    19. Data suggest that the transcription factor ZNF217 is a biomarker of poor prognosis and a therapeutic target in patients with breast cancer. PMID: 22728437
    20. study showed that high levels of expression of ZNF217 mRNA are associated with poor prognosis and the development of metastases in breast cancer; ZNF217 also promoted epithelial-mesenchymal transition (EMT) in mammary epithelial cells PMID: 22593193
    21. found ZNF217 gene amplification to be significantly correlated with lymph node metastasis (p<0.05) in ovarian clear cell carcinoma. Profound inhibition of cell migration and invasion was observed in siRNA-treated cells with ZNF217 amplification PMID: 22843878
    22. These findings indicate that ZNF217 overexpression is critical to growth and survival of OCCCs with ZNF217 gene amplification. PMID: 22139760
    23. multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain PMID: 21908891
    24. ZNF217 is overexpressed in GBMs and contributes to the maintenance of GSCs, which is regulated by HIFs released by the hypoxic environment of the tumor PMID: 21483406
    25. Data suggest that ZNF217 might play an important role in breast neoplastic progression and chemoresistance, and that Aurora-A might be involved in ZNF217-mediated effects. PMID: 21059223
    26. results show that ZNF217 regulates ErbB3 expression PMID: 20661224
    27. ZNF217 amplification was associated with medullary breast cancer. PMID: 20429623
    28. ZNF217 can be an important candidate gene responsible for the occurrence and progression of ovarian carcinomas. PMID: 19403395
    29. c-MYC amplification is an early event in breast cancer progression, while ZNF217 and Her2/neu amplification may play a role in the later stage of tumor development PMID: 15756435
    30. ZNF217 may promote neoplastic transformation by increasing cell survival during telomeric crisis and may promote later stages of malignancy by increasing cell survival during chemotherapy. PMID: 16203743
    31. These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP. PMID: 16940172
    32. implicate ZNF217 and its associated proteins in a novel pathway that may have profound effects on cancer progression PMID: 17130829
    33. ZNF217 and its associated pathways may provide new targets for therapeutic intervention in human cancers.[REVIEW] PMID: 17572303
    34. Suggest that ZNF217 might play a crucial role in the proliferation and invasion of ovarian cancer. PMID: 18425333
    35. These results establish the ZNF217 complex as a novel negative regulator of the p15(ink4b) gene and may constitute an important link between amplification of ZNF217 and the loss of TGF-beta responsiveness in breast cancer. PMID: 18625718
    36. ZNF217 assembles a distinct set of histone modifying proteins at target DNA sites that act synergistically in transcriptional repression. PMID: 19242095

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 13009

    OMIM: 602967

    KEGG: hsa:7764

    STRING: 9606.ENSP00000304308

    UniGene: Hs.155040

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