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  4. Recombinant Human Zinc finger and BTB domain-containing protein 38 (ZBTB38), partial

Recombinant Human Zinc finger and BTB domain-containing protein 38 (ZBTB38), partial

  • 中文名称：
    人ZBTB38重组蛋白
  • 货号：
    CSB-YP818747HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZBTB38重组蛋白
  • 货号：
    CSB-EP818747HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZBTB38重组蛋白
  • 货号：
    CSB-EP818747HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZBTB38重组蛋白
  • 货号：
    CSB-BP818747HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZBTB38重组蛋白
  • 货号：
    CSB-MP818747HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZBTB38
  • Uniprot No.：
    Q8NAP3
  • 别名：
    CIBZ; FLJ22332; FLJ31131; FLJ35036; ZBT38_HUMAN; ZBTB38; Ziinc finger and BTB domain containing protein 38; Zinc finger and BTB domain-containing protein 38
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner. Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication. Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons.
  • 基因功能参考文献：
    1. Results show that ZBTB38 knockdown significantly inhibits autophagic expression and downregulates RB1CC1 expression in SHSY5Y cells. Its overexpression upregulates RB1CC1 expression and enhances autophagy in spinal cord injury mice model. PMID: 30075197
    2. rescue of Zbtb38 can alleviate secondary damage of spinal cord through inhibition of ER stress-associated apoptosis, which provides a novel therapeutic regimen that targeting Zbtb38 may promote functional recovery of spinal cord for patients with SCI. PMID: 28514761
    3. ZBTB38 regulates replication efficiency by controlling MCM10 transcription. PMID: 24726359
    4. The nonsynonymous SNP (rs16851435:T > G,p.Ser319Ala) of ZBTB38 contributed to susceptibility of idiopathic short stature in the Chinese Han population. PMID: 23302005
    5. Alternative splicing of human height-related zinc finger and BTB domain-containing 38 gene through Alu exonization PMID: 21188497
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20846217
    7. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20966902
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 20546612
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20189936
    10. ZBTB38 binds methylated methylated CpGs in vitro and in vivo and represses transcrption. PMID: 16354688
    11. There was strongest association with SNPs in the ZBTB38 gene and adult human height. PMID: 18391951
    12. Observational study of gene-disease association. (HuGE Navigator) PMID: 19266077

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 数据库链接：

    HGNC: 26636

    OMIM: 612218

    KEGG: hsa:253461

    STRING: 9606.ENSP00000406955

    UniGene: Hs.518301

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