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  4. Recombinant Human Zinc finger and BTB domain-containing protein 17 (ZBTB17), partial

Recombinant Human Zinc finger and BTB domain-containing protein 17 (ZBTB17), partial

  • 中文名称：
    人ZBTB17重组蛋白
  • 货号：
    CSB-YP613380HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZBTB17重组蛋白
  • 货号：
    CSB-EP613380HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZBTB17重组蛋白
  • 货号：
    CSB-EP613380HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZBTB17重组蛋白
  • 货号：
    CSB-BP613380HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZBTB17重组蛋白
  • 货号：
    CSB-MP613380HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZBTB17
  • Uniprot No.：
    Q13105
  • 别名：
    Miz-1; Myc-interacting zinc finger protein 1; Myc-interacting zinc finger protein; ZBT17; ZBT17_HUMAN; Zbtb17; Zinc finger and BTB domain containing protein 17; Zinc finger and BTB domain-containing protein 17; Zinc finger protein 151; Zinc finger protein 60; ZNF151; ZNF60
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1.
  • 基因功能参考文献：
    1. Because RPL23 is encoded by a target gene of c-Myc, the RPL23/Miz-1/c-Myc regulatory circuit provides a feedback loop that links efficient RPL23 expression with c-Myc's function to suppress Miz-1-induced Cdk inhibitors and thereby leads to apoptotic resistance in higher-risk myelodysplastic syndrome patients PMID: 28539603
    2. This study firstly associates ZBTB17 loss-of-function mutation with enhanced susceptibility to DCM in humans, which provides novel insight into the molecular mechanism underpinning DCM, implying potential implications for genetic counseling and personalized management of DCM PMID: 29445930
    3. These data suggest that MYC acts as a master coordinator that inversely modulates the impact of cell cycle and circadian clock on gene expression via its interaction with MIZ1. PMID: 27339797
    4. strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1/BCL6 and of Miz1/NAC1 are reported PMID: 25484205
    5. Miz1 is a newly identified ING4-induced target gene which can drive prostate luminal epithelial cell differentiation. PMID: 27527891
    6. The mechanism of inhibition of c-Myc transcriptional activity by Miz-1 that binds c-Myc while competing for binding with Max has been described. PMID: 27859590
    7. This study used NMR to deduce the role of Miz-1 Zinc Fingers 1-4 in detecting the Miz-1 consensus sequence and preventing nonspecific DNA binding. PMID: 28035002
    8. the silencing of Miz-1 expression inhibited cell proliferation and promoted apoptosis in vitro and reduced the migration ability in esophageal carcinoma cells. PMID: 27109891
    9. This study presents the structure of the synthetic Miz-1 Zinc Finger 13 determined by 2D (1)H-(1)H NMR. PMID: 26972249
    10. results indicate that Miz-1 may be directed in vivo to the novel motif sequences we have identified, where it can recruit its specific binding partners to control gene expression and ultimately regulate cell fate PMID: 24983942
    11. MIZ-1 can promote the proliferation of breast cancer cells through Wnt signaling. PMID: 25558878
    12. We demonstrate that Arnt is an interaction partner for Miz-1, and that Arnt has a functional role in the regulation of CDKN2B PMID: 24618291
    13. The functional interaction of both proteins becomes apparent at oncogenic expression levels of MYC and association with MIZ-1 mediates both oncogenic functions of MYC as well as tumor-suppressive responses to oncogenic levels of MYC. PMID: 24296348
    14. The ZBTB17 polymorphism rs10927875 appears to play a role in the susceptibility of the Han Chinese population to dilated cardiomyopathy . PMID: 23570452
    15. The repression of TNF-alpha-induced JNK activation by Miz1 is de-repressed by its own site-specific ubiquitination and degradation. PMID: 22184250
    16. study demonstrate that HPV-16 E7 forms a complex with Miz-1; These findings suggest that HPV-16 E7 protein can repress Miz-1-induced p21(Cip1) gene expression PMID: 22099967
    17. NLRR3 is a direct target of MYCN, which associates with Miz-1 and negatively regulates NLRR3 expression. PMID: 21908575
    18. Miz1 and Myc affect the activity of the Atr checkpoint through their effect on TopBP1 chromatin association and stability. PMID: 18923429
    19. The ribosomal protein L23 is a negative regulator of Miz1-dependent transactivation. PMID: 19160485
    20. These results identify an important function for BCL6 in facilitating apoptosis of germinal center B cells via suppression of BCL2, and suggest that blocking this pathway is critical for lymphomagenesis. PMID: 19549844
    21. Binding of Arf disrupts the interaction of Miz1 with its coactivator, nucleophosmin, induces the sumoylation of Miz1, and facilitates the assembly of a heterochromatic complex that contains Myc and trimethylated H3K9 in addition to Miz1. PMID: 20308430
    22. Miz1 BTB domain resembles a typical swapped BTB dimer, although it has a shorter N-terminus that is not able to form the interchain sheet PMID: 20493880
    23. Although the transient repression mediated by Miz-1/c-Myc is independent of de novo methylation, the stable repression by this complex is associated with CpG island methylation of the critical -295 to -95-bp region of the WIF-1 promoter PMID: 20697356
    24. Miz-1 acts as a p53 suppressor by interfering with p53 DNA-binding ability PMID: 19901969
    25. repression of p21 promoter/reporters as well as the endogenous p21 gene by Myc depends on interaction with Miz-1. Expression of Miz-1 increases during hematopoietic differentiation and Miz-1 activates the p21 promoter under conditions of low Myc levels PMID: 12545156
    26. Miz-1 has a role in inducing apoptosis along with MAGE-A4 PMID: 14739298
    27. replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes PMID: 16167342
    28. Miz-1 targeting is essential for Myc-mediated apoptosis PMID: 16352593
    29. Miz-1 transcription factor was identified as an interactor of the SB transposase PMID: 16537485
    30. NDRG2 expression is repressed by Myc via Miz-1-dependent interaction with the NDRG2 core promoter PMID: 17050536
    31. repression of BCL2 transcription is the single essential consequence of targeting the MIZ-1 pathway during apoptosis induction, which explains a copperative interaction between c-MYC and BCL2 PMID: 17082179
    32. The crystal structure of the Miz-1 POZ domain show that the beta-sheet interface directs the tetramerisation of the Miz-1 POZ domain in solution. PMID: 17880999
    33. MIZ-1 is a new favorable neuroblastoma gene, which may directly or indirectly regulate the expression of other favorable neuroblastoma genes PMID: 17947461
    34. Gfi-1 does not directly bind to CDKN2B, but interacts with Miz-1 and, via Miz-1, is recruited to the core promoter of CDKN2B PMID: 19164764
    35. transcription factor Myc-interacting zinc-finger protein 1 (Miz1) selectively suppresses TNF-alpha-induced JNK1 activation and cell death independently. PMID: 19815509

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in germinal center B-cells.
  • 数据库链接：

    HGNC: 12936

    OMIM: 604084

    KEGG: hsa:7709

    STRING: 9606.ENSP00000364895

    UniGene: Hs.433764

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