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  4. Recombinant Human Zinc finger BED domain-containing protein 6 (ZBED6), partial

Recombinant Human Zinc finger BED domain-containing protein 6 (ZBED6), partial

  • 中文名称：
    人ZBED6重组蛋白
  • 货号：
    CSB-YP309619HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZBED6重组蛋白
  • 货号：
    CSB-EP309619HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZBED6重组蛋白
  • 货号：
    CSB-EP309619HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZBED6重组蛋白
  • 货号：
    CSB-BP309619HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZBED6重组蛋白
  • 货号：
    CSB-MP309619HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZBED6
  • Uniprot No.：
    P86452
  • 别名：
    ZBED6; Zinc finger BED domain-containing protein 6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific. Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP. Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females. Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription. Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2. Positively regulates the cell cycle and survival of pancreatic beta cells. Binds to the CDH2 gene and may directly repress CDH2 transcription. Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells. May also play a role in embryonic beta cell differentiation. May play a role in insulin sensitivity and glucose clearance.
  • 基因功能参考文献：
    1. results of this study show that the effect of ZBED6 on tumor development depends on the genetic background and the transcriptional state of its target genes PMID: 26056301
    2. Mouse MGR (Zbed6) is a repressor of Igf2. PMID: 20134481
    3. Silencing of Zbed6 in mouse C2C12 myoblasts affected Igf2 expression, cell proliferation, wound healing, and myotube formation. PMID: 20016685
  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus. Cytoplasm.
  • 组织特异性：
    Expressed in pancreatic islet cells (at protein level).
  • 数据库链接：

    HGNC: 33273

    OMIM: 613512

    KEGG: hsa:100381270

    STRING: 9606.ENSP00000447879

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