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  4. Recombinant Human WD repeat-containing protein 36 (WDR36), partial

Recombinant Human WD repeat-containing protein 36 (WDR36), partial

  • 中文名称：
    人WDR36重组蛋白
  • 货号：
    CSB-YP854163HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人WDR36重组蛋白
  • 货号：
    CSB-EP854163HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人WDR36重组蛋白
  • 货号：
    CSB-EP854163HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人WDR36重组蛋白
  • 货号：
    CSB-BP854163HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人WDR36重组蛋白
  • 货号：
    CSB-MP854163HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    WDR36
  • Uniprot No.：
    Q8NI36
  • 别名：
    WDR36; WD repeat-containing protein 36; T-cell activation WD repeat-containing protein; TA-WDRP
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.
  • 基因功能参考文献：
    1. Study suggests that WDR36 gene is involved in the pathogenesis of juvenile open-angle glaucoma in Taiwan population as a subordinate modifier gene. PMID: 29104481
    2. Meta-analysis does not support a significant role of WDR36 in the genetic susceptibility of primary open angle glaucoma or its subtypes. PMID: 28658128
    3. The association between WDR36 and POAG was not supported, and the majority of POAG cases did not harbor a potentially disease-causing variant in the remaining Mendelian genes. PMID: 28282485
    4. Familial linkage studies for primary angle-closure glaucoma have been performed and identified WDR36 causative primary angle-closure glaucoma disease PMID: 26497787
    5. According to molecular genetic studies, WDR36 causative gene involved in the development of Primary open-angle glaucoma. PMID: 25711070
    6. Single nucleotide polymorphism in the WDR36 gene, rs10038177 (c.710+30C>T), was found to be strongly associated with the high tension glaucoma cases, but not with controls in the East Indian population. PMID: 22025897
    7. Rare WDR36 variants and the P53 p.R72P polymorphism behaved as moderate glaucoma risk factors in Spanish patients. The authors provide evidence for a genetic interaction between WDR36 and P53 variants in glaucoma susceptibility. PMID: 21931130
    8. WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Galphaq and phospholipase C beta 2 in a signalling complex PMID: 21940795
    9. WDR36 sequence variance was only a rare cause of primary open-angel glaucoma glaucoma in Italian families with glaucoma. PMID: 20813748
    10. Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg PMID: 20198978
    11. role in etiology of both high- and low-pressure glaucoma. PMID: 15677485
    12. Our results provided mapping of a novel locus for juvenile-onset primary open angle glaucoma at 5q and excluded coding or splicing junctions mutations within the WDR36 gene. PMID: 16518310
    13. The association of WDR36 sequence variants with more severe disease in affected individuals suggests that defects in the WDR36 gene can contribute to POAG and that WDR36 may be a glaucoma modifier gene. PMID: 16723468
    14. The WDR36 D658G is a neutral variant in the Australian population. PMID: 16876519
    15. The finding that the WDR36 gene is probably not the responsible gene in this family further documents the genetic heterogeneity of POAG (primary open-angle glaucoma). PMID: 16966629
    16. WDR36 gene variants may be only rare causes of normal tension glaucoma in the German population. PMID: 17563723
    17. One nonsynonymous variant, p.S664L, and association of allelic variants (p.I264V and c.1965-30A>G) in WDR36 and their prevalence in unrelated Japanese patients with high tension glaucoma (HTG) suggest they are probably involved in pathogenesis of HTG. PMID: 17960130
    18. The occurrence of several rare putative disease-causing variants in patients with glaucoma suggests that WDR36 may be a minor disease-causing gene in glaucoma, at least in the German population. PMID: 18172102
    19. Timolol can reduce MYOC RNA levels in HTM cultures from some individuals. Timolol does not alter OPTN or WDR36 levels or ameliorate MYOC induction by dexamethasone in vitro. PMID: 18195223
    20. WDR36 sequence variants can lead to an altered cellular phenotype, supporting the theory that WDR36 participates in polygenic forms of glaucoma. PMID: 19150991
    21. WDR36 is associated with sporadic high tension glaucoma but not with normal tension glaucoma or juvenile-onset primary open-angle glaucoma. PMID: 19347049
    22. First series of WDR36 mutations in subjects with high- and low-pressure adult-onset primary open angle glaucoma. First mRNA expression profiling of this gene in various ocular and non-ocular tissues for human and mouse. PMID: 15677485

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  • 相关疾病：
    Glaucoma 1, open angle, G (GLC1G)
  • 亚细胞定位：
    Nucleus, nucleolus.
  • 组织特异性：
    Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve.
  • 数据库链接：

    HGNC: 30696

    OMIM: 609669

    KEGG: hsa:134430

    STRING: 9606.ENSP00000423067

    UniGene: Hs.533237

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