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  4. Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2), partial

Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2), partial

  • 中文名称：
    Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2(CACNA2D2) ,partial
  • 货号：
    CSB-YP889145HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2(CACNA2D2) ,partial
  • 货号：
    CSB-EP889145HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2(CACNA2D2) ,partial
  • 货号：
    CSB-EP889145HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2(CACNA2D2) ,partial
  • 货号：
    CSB-BP889145HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2(CACNA2D2) ,partial
  • 货号：
    CSB-MP889145HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CACNA2D2
  • Uniprot No.：
    Q9NY47
  • 别名：
    Alpha 2 delta calcium channel subunit ; CA2D2_HUMAN; CACNA2D; Cacna2d2; Calcium channel, voltage-dependent, alpha 2/delta subunit 2; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26; Calcium voltage gated channel auxiliary subunit alpha2delta 2; Gene 26; KIAA0558; LUAC11.1; Voltage-dependent calcium channel subunit alpha-2/delta-2; Voltage-dependent calcium channel subunit delta-2; Voltage-gated calcium channel subunit alpha-2/delta-2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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CACNA2D2 antibodies

靶点详情

  • 功能：
    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
  • 基因功能参考文献：
    1. show that the action of alpha2delta2 on tumor development occurs not only through a stimulation of proliferation PMID: 25619833
    2. The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1, ABCB1 and the calcium channel complex subunit CACNA2D2, is reported. PMID: 23402298
    3. CACNA2D2 deletion/methylation is associated with cervical disease progression. PMID: 21809394
    4. single nucleotide polymorphism identified PMID: 11851383
    5. role in apoptosis in non-small cell lung cancer cells via association with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity PMID: 12555074
    6. In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia, enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans. PMID: 15331424
    7. Although transgenic du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in Purkinje somatic calcium currents or increase in cerebellar tyrosine hydroxylase gene expression. PMID: 17135419

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Calcium channel subunit alpha-2/delta family
  • 组织特异性：
    Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta an
  • 数据库链接：

    HGNC: 1400

    OMIM: 607082

    KEGG: hsa:9254

    STRING: 9606.ENSP00000418081

    UniGene: Hs.476273

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