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  4. Recombinant Human Urea transporter 2 (SLC14A2), partial

Recombinant Human Urea transporter 2 (SLC14A2), partial

  • 中文名称：
    人SLC14A2重组蛋白
  • 货号：
    CSB-YP620898HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC14A2重组蛋白
  • 货号：
    CSB-EP620898HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC14A2重组蛋白
  • 货号：
    CSB-EP620898HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC14A2重组蛋白
  • 货号：
    CSB-BP620898HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC14A2重组蛋白
  • 货号：
    CSB-MP620898HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC14A2
  • Uniprot No.：
    Q15849
  • 别名：
    FLJ16167; hUT-A6; HUT2; kidney; MGC119566; MGC119567; Slc14a2; Solute carrier family 14 (urea transporter), member 2; Solute carrier family 14 member 2; Urea transporter 2; Urea transporter; Urea transporter, kidney; UT-A2; UT2; UT2_HUMAN; UTA; UTR
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.
  • 基因功能参考文献：
    1. The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands. The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased. PMID: 29279852
    2. UT2 is a negative regulator shared across STAT3 and mTORC2 signaling cascades, functioning as a tumor suppressor in hematologic malignancies driven by those pathways. PMID: 26927669
    3. Studies indicate that the urea transporter SLC14a2, the UT-A group, was originally isolated from kidney inner medulla. PMID: 25298338
    4. Studies indicate that osmotic diuresis, where urea concentrations are low, can prompt an increase in urea transporter abundance. PMID: 25298340
    5. Studies indicate that the cell signaling pathway for vasopressin-mediated urea transporters phosphorylation and activity involves two cAMP-dependent signaling pathways. PMID: 25298341
    6. HUT2 gene may play a certain role in developing metabolic syndrome and its related traits in Asian population. PMID: 20797394
    7. a novel UT-A urea transporter; the transcript contains a novel 129-bp exon, exon 5a, which, as a result of alternative splicing, introduces a unique 19-aa segment and a stop codon. PMID: 15189812
    8. results provide new evidences that suggest the involvement of AQP9 and UT-A in the urea excretion mechanism across human term placenta from mother to fetus in physiological conditions PMID: 16480766
    9. This review summarizes the published work that has accrued on the structure and regulation of these genes. PMID: 17264986
    10. polymorphisms in the SLC14A2 gene can predict the antihypertensive efficacy of nifedipine GITS (gastrointestinal therapeutic system) PMID: 17344938

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  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Urea transporter family
  • 组织特异性：
    Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney.
  • 数据库链接：

    HGNC: 10919

    OMIM: 601611

    KEGG: hsa:8170

    STRING: 9606.ENSP00000255226

    UniGene: Hs.710927

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