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  4. Recombinant Human Up-regulator of cell proliferation (URGCP), partial

Recombinant Human Up-regulator of cell proliferation (URGCP), partial

  • 中文名称：
    人URGCP重组蛋白
  • 货号：
    CSB-YP837434HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人URGCP重组蛋白
  • 货号：
    CSB-EP837434HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人URGCP重组蛋白
  • 货号：
    CSB-EP837434HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人URGCP重组蛋白
  • 货号：
    CSB-BP837434HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人URGCP重组蛋白
  • 货号：
    CSB-MP837434HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    URGCP
  • Uniprot No.：
    Q8TCY9
  • 别名：
    FLJ20654; HBV X protein up-regulated gene 4 protein; HBV X protein upregulated gene 4 protein; HBxAg up-regulated gene 4 protein; HBxAg upregulated gene 4 protein; KIAA1507; Up-regulator of cell proliferation; Upregulated gene 4; Upregulator of cell proliferation; URGCP; URGCP_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.
  • 基因功能参考文献：
    1. Relationship between URG4/URGCP expression and clinicopathologic characteristics were evaluated and significant results were in various cancer types (review). PMID: 29775749
    2. miR-519 inhibited URG4 expression by directly binding to the 3'UTR of URG4. miR-519 inhibited Cyclin D1 expression and the phosphorylation level of Rb, and increased p21 and p27 expression, confirming miR-519 blocked G1/S transition. PMID: 28315691
    3. Findings indicate that URGCP plays an important role in promoting NSCLC cell invasion and metastasis by enhancing NF-kappaB-activated MMP-9 expression PMID: 26429875
    4. site-directed mutagenesis of potential SP1 binding sites diminished both DNA-protein complexes and SP1-mediated upregulation of URG-4 promoter activity. These findings are valuable for understanding transcriptional regulation of URG4/URGCP that has a pivotal role in cancer progression. PMID: 27766531
    5. FA caused a decrease in the expression of novel gene URG4/URGCP. PMID: 26334619
    6. URG4 overexpression increased the resistance to cisplatin-induced apoptosis in bladder cancer. PMID: 26429874
    7. We presented first mechanisms of TMZ and URG4/URGCP relationship in neuroblastoma cells in this study. As a result, TMZ may be a novel candidate agent for treatment of neuroblastoma as a single or agent or together with other therapeutic agents PMID: 25835972
    8. This study suggests that URG4/URGCP plays an important pro-angiogenic role in HCC via a mechanism linked to activation of the NF-kappaB pathway PMID: 25947641
    9. URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer. PMID: 25427922
    10. Data suggest that neuroblastoma (NB) cell differentiation might associate with peroxisome proliferator-activated receptor alpha (PPARalpha) and URG4/URGCP gene expression profile after retinoic acid (RA) treatment. PMID: 23821302
    11. Rapamycin diminishes URGCP gene expression in DU145 and PC3 cells, but increases expression in LNCaP cells. PMID: 23007575
    12. microRNA profiles were analyzedin HepG2 cells in presence or absence of URG4/URGCP gene using RNA interference. PMID: 23053999
    13. The effects of URGCP/URG4-overexpression or -knockdown on expression of cell cycle regulators and transcriptional activity of FOXO3a, were examined. PMID: 22815774
    14. higher expression of URG4 in our 2 patients suggests that URG4 might be involved in leukemogenesis PMID: 22677619
    15. The data suggest that URG4 may play an important role in the development of hepatocellular carcinoma by partially regulating the expression of cyclin D1. PMID: 20714998
    16. Expression of URG4 in hepatocellular carcinoma is closely related with the expression of HBx. PMID: 20491173
    17. URG4 may be a natural effector of HBxAg that contributes importantly to multistep hepatocarcinogenesis. PMID: 12082552
    18. URG4 plays an important role in the development of human gastric cancer by regulating the expression of cyclin D1. PMID: 17217616
    19. URG4 may play important roles in the development of osteosarcoma, and might be a useful molecular marker for predicting the prognosis of osteosarcoma. PMID: 18972316

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, Very large inducible GTPase (VLIG) family
  • 组织特异性：
    Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.
  • 数据库链接：

    HGNC: 30890

    OMIM: 610337

    KEGG: hsa:55665

    STRING: 9606.ENSP00000396918

    UniGene: Hs.663312

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