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  4. Recombinant Human Ubiquitin carboxyl-terminal hydrolase 36 (USP36), partial

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 36 (USP36), partial

  • 中文名称：
    人USP36重组蛋白
  • 货号：
    CSB-YP878959HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人USP36重组蛋白
  • 货号：
    CSB-EP878959HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人USP36重组蛋白
  • 货号：
    CSB-EP878959HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人USP36重组蛋白
  • 货号：
    CSB-BP878959HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人USP36重组蛋白
  • 货号：
    CSB-MP878959HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    USP36
  • Uniprot No.：
    Q9P275
  • 别名：
    Deubiquitinating enzyme 1; Deubiquitinating enzyme 36; DUB1; FLJ12851; KIAA1453; Ubiquitin carboxyl-terminal hydrolase 36; Ubiquitin specific peptidase 36; Ubiquitin specific processing protease 36; Ubiquitin thioesterase 36; Ubiquitin thiolesterase 36; Ubiquitin-specific-processing protease 36; UBP36_HUMAN; Usp36
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm. Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions. Deubiquitinates SOD2, regulates SOD2 protein stability. Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins.
  • 基因功能参考文献：
    1. Together, our results reveal USP36 as a novel H2B deubiquitinase and shed light on its additional functions in regulating gene expression. PMID: 29274341
    2. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation. PMID: 27445338
    3. USP36 is a crucial and bono fide deubiquitinating enzyme controlling c-Myc's nucleolar degradation pathway PMID: 25775507
    4. Recently, much progress has been made in understanding the physiological functions of cytokine-inducible DUBs such as DUB-1, DUB-2, and DUB-3/USP17, in regulation of cell proliferation and apoptosis in lymphocytes. [review] PMID: 23773437
    5. USP36 controls selective autophagy activation in Drosophila and in human cells. PMID: 22622177
    6. The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein, cytoplasmic 1 gene. PMID: 22865700
    7. Study identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2. PMID: 21268071
    8. DUB-1 is present ubuquitously within cells and has deubiitinating enzyme activity in vivo and in vitro. PMID: 15254734
    9. indentification of deubiquitinating enzyme activity of USP36 by analyzing its capability to cleave the ubiquitin PMID: 15809067
    10. USP36 is overexpressed in ovarian cancer compared to normal ovary and its transcripts were identified in ascites and serum of ovarian cancer patients PMID: 18566677
    11. Results suggest that by deubiquitylating various nucleolar substrate proteins including nucleophosmin/B23 and fibrillarin, USP36 plays a crucial role in regulating the structure and function of nucleoli. PMID: 19208757
    12. Data suggest that nucleophosmin/B23 recruits USP36 to nucleoli, thereby serving as a platform for the regulation of nucleolar protein functions through ubiquitylation/deubiquitylation. PMID: 19679658

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  • 亚细胞定位：
    Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    Peptidase C19 family
  • 组织特异性：
    Broadly expressed.
  • 数据库链接：

    HGNC: 20062

    OMIM: 612543

    STRING: 9606.ENSP00000310590

    UniGene: Hs.464243

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