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  4. Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8), partial

Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8), partial

  • 中文名称：
    人UGT1A8重组蛋白
  • 货号：
    CSB-YP867187HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人UGT1A8重组蛋白
  • 货号：
    CSB-EP867187HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人UGT1A8重组蛋白
  • 货号：
    CSB-EP867187HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人UGT1A8重组蛋白
  • 货号：
    CSB-BP867187HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人UGT1A8重组蛋白
  • 货号：
    CSB-MP867187HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UGT1A8
  • Uniprot No.：
    Q9HAW9
  • 别名：
    UGT1A8; GNT1; UGT1; UDP-glucuronosyltransferase 1A8; UGT1A8; UDP-glucuronosyltransferase 1-8; UDPGT 1-8; UGT1*8; UGT1-08; UGT1.8; UDP-glucuronosyltransferase 1-H; UGT-1H; UGT1H
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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UGT1A8 Proteins

靶点详情

  • 功能：
    UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens. Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent.; Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
  • 基因功能参考文献：
    1. UGT1A8 gene polymorphisms can affect the activity of UDP glucuronosyltransferase enzyme, which may influence the elimination of mycophenolate mofetil in different patients. PMID: 29025387
    2. Polymorphism of UGT1A8 rs1042597-G variant allele is associated with colorectal cancer. PMID: 29282011
    3. the in vitro glucuronidation of raloxifene in humans and monkeys was examined using liver and intestinal microsomes and recombinant UGT enzymes (UGT1A1, UGT1A8 and UGT1A9). PMID: 26247833
    4. Data suggest UGT1A8 is involved in differential metabolism of dietary flavonoids (glucosides and aglycones); glucuronidation of flavonoid glucosides is considerably slower than glucuronidation of flavonoid aglycones in microsomes of intestine/liver. PMID: 26317684
    5. Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1alpha and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid. PMID: 23721685
    6. UGT1A8 Polymorphism is associated with response to raloxifene in breast cancer. PMID: 23682072
    7. A much higher frequency of UGT1A8*2 variant allele was found in Chinese than in Caucasians and Africans PMID: 23700788
    8. The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma. PMID: 22367021
    9. In a study of Japanese renal transplant recipients, there are no significant differences in the area under the plasma concentration-time curve ratio of mycophenolic acid (MPA) glucuronide/MPA between UGT1A8 I399C/T genotypes. PMID: 18695635
    10. Results show UGT1A8 mRNA expression in primary hepatocytes by semi-quantitative RT-PCR. PMID: 17603215
    11. The effect of UGT1A8 and UGT1A9 variants on mycophenolic acid metabolism appears to be modified by concomitant calcineurin inhibitor therapy. PMID: 18568343
    12. the effect of UGT1A8 polymorphism on the pharmacokinetics of mycophenolic acid (MPA) and its metabolites phenolic glucuronide (MPAG) and acyl glucuronide (AcMPAG) in Chinese renal transplant PMID: 18946804

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    UDP-glycosyltransferase family
  • 组织特异性：
    [Isoform 1]: Expressed in kidney, colon and small intestine. Not expressed in liver.; [Isoform 2]: Expressed in liver, kidney, colon and small intestine.
  • 数据库链接：

    HGNC: 12540

    OMIM: 191740

    KEGG: hsa:54576

    STRING: 9606.ENSP00000362549

    UniGene: Hs.554822

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