Your Good Partner in Biology Research

中文简体

CSF2｜ CTLA4｜ DLL3｜ EGFR｜ IL4｜ IL4R｜ LAG3｜ MSTN｜ NECTIN4｜ NT5E｜ SEZ6｜ TM4SF1｜ TNFSF13｜ TPO

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Tyrosine-protein phosphatase non-receptor type 4 (PTPN4), partial

Recombinant Human Tyrosine-protein phosphatase non-receptor type 4 (PTPN4), partial

  • 中文名称：
    人PTPN4重组蛋白
  • 货号：
    CSB-YP019041HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PTPN4重组蛋白
  • 货号：
    CSB-EP019041HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PTPN4重组蛋白
  • 货号：
    CSB-EP019041HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PTPN4重组蛋白
  • 货号：
    CSB-BP019041HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PTPN4重组蛋白
  • 货号：
    CSB-MP019041HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PTPN4
  • Uniprot No.：
    P29074
  • 别名：
    MEG; megakaryocyte phosphatase; megakaryocyte protein-tyrosine phosphatase; Protein tyrosine phosphatase MEG1; Protein tyrosine phosphatase; megakaryocyte; protein tyrosine phosphatase; non-receptor type 4 (megakaryocyte); Protein-tyrosine phosphatase MEG1; PTN4; PTN4_HUMAN; PTPase MEG1; PTPase-MEG1; PTPMEG; PTPMEG1; Ptpn4; Tyrosine protein phosphatase non receptor type 4; Tyrosine-protein phosphatase non-receptor type 4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

相关产品

PTPN4 antibodies

靶点详情

  • 功能：
    Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton.
  • 基因功能参考文献：
    1. Binding assays confirmed that three (Cyto8-mtxd-1, Cyto8-mtxk-4 and Cyto8-mtxd-1k-4) out of the five designed peptides exhibit moderately or considerably increased affinity as compared to the native peptide Cyto8-RETEV PMID: 27923202
    2. the p38gamma.PTPN4 interaction promotes cellular signaling, preventing cell death induction. PMID: 27246854
    3. Deletion of PTPN4 has been reported in monozygotic twins with a Rett syndrome-like phenotype. PMID: 25424712
    4. The physiologically active PTPN4 two-domain (the PDZ and the phosphatase domains) adopts a predominant compact conformation in solution. PDZ ligand binding restores the catalytic competence of PTPN4 disrupting the transient interdomain communication. PMID: 25158884
    5. These findings suggest that PTPN4 negatively regulates cell proliferation and motility through dephosphorylation of CrkI. PMID: 23666597
    6. PTPN4 is dispensable for T cell development and/or T cell effector functions. PMID: 18614237

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 数据库链接：

    HGNC: 9656

    OMIM: 176878

    KEGG: hsa:5775

    STRING: 9606.ENSP00000263708

    UniGene: Hs.469809

Most popular with customers

产品中心
特别关注


X
九游平台-九游(中国) | 米兰体育-米兰体育（中国） | 开云手机在线登陆入口 | 江南官方体育网页版 | 开云网页版 | 开云官方在线入口 | 开云电子体育 | 开云官方链接 | 江南网页版页面登录 |