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  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Tuftelin (TUFT1)

Recombinant Human Tuftelin (TUFT1)

  • 中文名称：
    人TUFT1重组蛋白
  • 货号：
    CSB-YP868268HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TUFT1重组蛋白
  • 货号：
    CSB-EP868268HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TUFT1重组蛋白
  • 货号：
    CSB-EP868268HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TUFT1重组蛋白
  • 货号：
    CSB-BP868268HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TUFT1重组蛋白
  • 货号：
    CSB-MP868268HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TUFT1
  • Uniprot No.：
    Q9NNX1
  • 别名：
    MGC188530; TUFT1; TUFT1_HUMAN; Tuftelin 1; Tuftelin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-390
  • 氨基酸序列
    MNGTRNWCTL VDVHPEDQAA GSVDILRLTL QGELTGDELE HIAQKAGRKT YAMVSSHSAG HSLASELVES HDGHEEIIKV YLKGRSGDKM IHEKNINQLK SEVQYIQEAR NCLQKLREDI SSKLDRNLGD SLHRQEIQVV LEKPNGFSQS PTALYSSPPE VDTCINEDVE SLRKTVQDLL AKLQEAKRQH QSDCVAFEVT LSRYQREAEQ SNVALQREED RVEQKEAEVG ELQRRLLGME TEHQALLAKV REGEVALEEL RSNNADCQAE REKAATLEKE VAGLREKIHH LDDMLKSQQR KVRQMIEQLQ NSKAVIQSKD ATIQELKEKI AYLEAENLEM HDRMEHLIEK QISHGNFSTQ ARAKTENPGS IRISKPPSPK PMPVIRVVET
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the mineralization and structural organization of enamel.
  • 基因功能参考文献：
    1. TUFT1 may affect HIF1-Snail signaling in pancreatic neoplasms, regulating epithelial mesenchymal transition and metastasis. PMID: 27566398
    2. A nonsynonymous single nucleotide variant rs41310883 in TUFT1 plays a role in chondrocyte differentiation and cartilage mineralization apparently on a calcium-related pathway, and thus can be considered as a novel susceptibility gene metatarsophalangeal osteoarthritis. PMID: 28410428
    3. the statistically significant association of rs2337359 upstream of TUFT1 with dental caries experience via meta-analysis across adult samples (p < 0.002) and the suggestive association for multiple variants in TFIP11 across child samples PMID: 25373699
    4. We found evidence for a trend of association between genetic variation of TUFT1 and TFIP11 and MIH, which suggest these genes are potentially involved in individual predisposition to MIH. PMID: 23790503
    5. Human tuftelin gene contains 13 exons and is larger than 26 kb, with two alternatively spliced tuftelin mRNA transcripts now been identified in the human tooth bud. PMID: 11733143
    6. The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues. Review. PMID: 12489194
    7. The CT genotype of the tuftelin rs3790506 marker was overrepresented in cases with dmft scores higher than 5 and dmfs scores higher than 6 compared to controls. PMID: 18781068

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Tuftelin family
  • 组织特异性：
    Present in the extracellular enamel and is mainly associated with the crystal component.
  • 数据库链接：

    HGNC: 12422

    OMIM: 600087

    KEGG: hsa:7286

    STRING: 9606.ENSP00000357842

    UniGene: Hs.489922

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