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  4. Recombinant Human Tubulin--tyrosine ligase-like protein 12 (TTLL12)

Recombinant Human Tubulin--tyrosine ligase-like protein 12 (TTLL12)

  • 中文名称：
    人TTLL12重组蛋白
  • 货号：
    CSB-YP622755HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TTLL12重组蛋白
  • 货号：
    CSB-EP622755HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TTLL12重组蛋白
  • 货号：
    CSB-EP622755HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TTLL12重组蛋白
  • 货号：
    CSB-BP622755HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TTLL12重组蛋白
  • 货号：
    CSB-MP622755HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TTLL12
  • Uniprot No.：
    Q14166
  • 别名：
    dJ526I14.2; FLJ41795; KIAA0153; TTL12_HUMAN; TTLL12; Tubulin tyrosine ligase like family; member 12; Tubulin--tyrosine ligase-like protein 12
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-644
  • 氨基酸序列
    MEAERGPERR PAERSSPGQT PEEGAQALAE FAALHGPALR ASGVPERYWG RLLHKLEHEV FDAGEVFGIM QVEEVEEEED EAAREVRKQQ PNPGNELCYK VIVTRESGLQ AAHPNSIFLI DHAWTCRVEH ARQQLQQVPG LLHRMANLMG IEFHGELPST EAVALVLEEM WKFNQTYQLA HGTAEEKMPV WYIMDEFGSR IQHADVPSFA TAPFFYMPQQ VAYTLLWPLR DLDTGEEVTR DFAYGETDPL IRKCMLLPWA PTDMLDLSSC TPEPPAEHYQ AILEENKEKL PLDINPVVHP HGHIFKVYTD VQQVASSLTH PRFTLTQSEA DADILFNFSH FKDYRKLSQE RPGVLLNQFP CENLLTVKDC LASIARRAGG PEGPPWLPRT FNLRTELPQF VSYFQQRERW GEDNHWICKP WNLARSLDTH VTKSLHSIIR HRESTPKVVS KYIESPVLFL REDVGKVKFD IRYIVLLRSV RPLRLFVYDV FWLRFSNRAF ALNDLDDYEK HFTVMNYDPD VVLKQVHCEE FIPEFEKQYP EFPWTDVQAE IFRAFTELFQ VACAKPPPLG LCDYPSSRAM YAVDLMLKWD NGPDGRRVMQ PQILEVNFNP DCERACRYHP TFFNDVFSTL FLDQPGGCHV TCLV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.
  • 基因功能参考文献：
    1. TTLL12 as a negative regulator of RNA-virus-induced type I IFN expression by inhibiting the interaction of VISA with other proteins. PMID: 28011935
    2. A new TTLL12 isoform may be of importance for proper maintenance of lung cancer cells. PMID: 27748896
    3. results suggest that hTTLL12 has non-catalytic functions related to tubulin and histone modification, which could be linked to its effects on mitosis and chromosome number stability PMID: 23251473
    4. Results raise the possibility that TTLL12 could contribute to tumorigenesis through effects on the cytoskeleton, tubulin modification and chromosome number stability. PMID: 20162578
  • 亚细胞定位：
    Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus.
  • 组织特异性：
    Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions.
  • 数据库链接：

    HGNC: 28974

    KEGG: hsa:23170

    STRING: 9606.ENSP00000216129

    UniGene: Hs.517670

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