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  4. Recombinant Human Troponin T, slow skeletal muscle (TNNT1)

Recombinant Human Troponin T, slow skeletal muscle (TNNT1)

  • 中文名称：
    人TNNT1重组蛋白
  • 货号：
    CSB-YP024015HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TNNT1重组蛋白
  • 货号：
    CSB-EP024015HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TNNT1重组蛋白
  • 货号：
    CSB-EP024015HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TNNT1重组蛋白
  • 货号：
    CSB-BP024015HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TNNT1重组蛋白
  • 货号：
    CSB-MP024015HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TNNT1
  • Uniprot No.：
    P13805
  • 别名：
    ANM; MGC104241; NEM5; Skeletal; Slow; slow skeletal muscle; Slow skeletal muscle troponin T; sTnT; Tnnt1; TNNT1_HUMAN; TNT; TnTs; Troponin T; Troponin T slow skeletal muscle; Troponin T type 1 (skeletal slow); troponin T1 skeletal slow; Troponin T1, slow skeletal type
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-278
  • 氨基酸序列
    MSDTEEQEYE EEQPEEEAAE EEEEAPEEPE PVAEPEEERP KPSRPVVPPL IPPKIPEGER VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELVALK ERIERRRSER AEQQRFRTEK ERERQAKLAE EKMRKEEEEA KKRAEDDAKK KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE MKVRILSERK KPLDIDYMGE EQLRARSAWL PPSQPSCPAR EKAQELSDWI HQLESEKFDL MAKLKQQKYE INVLYNRISH AQKFRKGAGK GRVGGRWK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能参考文献：
    1. High TNNT1 expression is associated with breast cancer. PMID: 30031058
    2. This study describes the first TNNT1 mutation that transmits in an autosomal dominant fashion to cause nemaline myopathy. PMID: 29178646
    3. investigated the effects of one of these mutations, K247R of TnT, on the picosecond dynamics of the Tn core domain (Tn-CD), consisting of TnC, TnI and TnT2 (183-288 residues of TnT), by carrying out the quasielastic neutron scattering measurements on the reconstituted Tn-CD containing either the wild-type TnT2 (wtTn-CD) or the mutant TnT2 (K247R-Tn-CD) in the absence and presence of Ca(2+) PMID: 28923663
    4. Data suggest that mutations in troponin C (TnC, A8V) and troponin T (TnT, delta14-TnT) found in patients with hypertrophic cardiomyopathy together fully stabilize the active M state of regulated actin (the actin-tropomyosin-troponin complex). PMID: 28530094
    5. pathogenesis of TNNT1 myopathies PMID: 27429059
    6. Copeptin and troponin T measurement could potentially improve the prehospital diagnostic and prognostic classification of patients with a suspected AMI. PMID: 27903076
    7. TNNT1 genetic and epigenetic variations are associated with HDL-C levels and coronary artery disease. PMID: 26950807
    8. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT. PMID: 26774798
    9. Nemaline body myopathy Palestinian patients were found to have a novel mutation in troponin T1. PMID: 26296490
    10. troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants PMID: 24625749
    11. Biopsy-proven acute and viral myocarditis is associated with elevated concentrations of hs-TnT. PMID: 24781421
    12. Troponin T1 blood levels had a positive association with increased risk for hypertrophic cardiomyopathy. PMID: 24020864
    13. TNNT1 DNA methylation levels were positively correlated with mean HDL particle size, HDL-phospholipid, HDL-apolipoprotein AI, HDL-C and TNNT1 expression levels. PMID: 23244308
    14. Human slow skeletal troponin T (HSSTnT) isoforms, despite being homologues of cardiac TnT may display distinct functional properties in muscle regulation. PMID: 22977240
    15. analysis of parameters of oxygen-dependent metabolism of neutrophils by NBT test and levels of vWF antigen in the serum can be used for predicting the risk of unfavorable outcome in patients with ACS and normal troponin T PMID: 22448368
    16. In heart failure patients with normal ejection fraction, highly sensitive troponin T and heart fatty acid binding protein are elevated independent of coronary artery disease. PMID: 21729325
    17. baseline cTnT levels are higher in patients with MPI evidence of reversible myocardial ischaemia than those without reversible ischaemia PMID: 22239123
    18. carotid-femoral pulse wave and office pulse pressure are associated with minimally elevated hsTnT levels in the elderly PMID: 21784424
    19. the hypertrophic phenotype associated with the TnT mutations can be characterized by a significant increase in disorder of rigor cross-bridges. PMID: 21683708
    20. Elevated serum troponin T levels are associated with different conditions related to the severity of hypertrophic cardiomyopathy. PMID: 21111984
    21. Cardiac troponin T and creatine kinase have roles in infarct size and left ventricular function after acute myocardial infarction PMID: 21448949
    22. The occurrence of myocardial infarction is associated with elevated troponin T levels. PMID: 19916752
    23. Among athletees, faster runners demonstrate significantly stronger cardoac TnT releases and inflammation signs. PMID: 20380359
    24. troponin-T mutations were responsible for 3% of the hypertrophic cardiomyopathy cases in our study population PMID: 20038417
    25. Troponin T may have a role in pulmonary embolism progeresion to death PMID: 19541721
    26. TNT is a biochemical marker of susceptibility to hypoxia in infants of type 1 diabetic mothers. PMID: 19690080
    27. Data suggest that inefficient incorporation into myofilament is responsible for the instability of mutant slow troponin T in Amish nemaline myopathy. PMID: 15665378
    28. Report adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease. PMID: 18579801
    29. slow TnT was encoded by two different transcripts in significantly different ratios in myotonic dystrophy type 1 and myotonic dystrophy type 2 muscles. PMID: 19326042

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  • 相关疾病：
    Nemaline myopathy 5 (NEM5)
  • 蛋白家族：
    Troponin T family
  • 数据库链接：

    HGNC: 11948

    OMIM: 191041

    KEGG: hsa:7138

    STRING: 9606.ENSP00000467176

    UniGene: Hs.631558

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