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  4. Recombinant Human Troponin I, slow skeletal muscle (TNNI1)

Recombinant Human Troponin I, slow skeletal muscle (TNNI1)

  • 中文名称：
    人TNNI1重组蛋白
  • 货号：
    CSB-YP024011HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TNNI1重组蛋白
  • 货号：
    CSB-EP024011HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TNNI1重组蛋白
  • 货号：
    CSB-EP024011HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TNNI1重组蛋白
  • 货号：
    CSB-BP024011HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TNNI1重组蛋白
  • 货号：
    CSB-MP024011HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TNNI1
  • Uniprot No.：
    P19237
  • 别名：
    2700018B22Rik; AI747285; DKFZp451O223 ; si:dz182n13.3; slow skeletal muscle; slow-twitch isoform; SSTNI; TNN1; Tnni1; TNNI1_HUMAN; Troponin I; Troponin I slow skeletal muscle; Troponin I slow twitch isoform ; troponin I type 1 (skeletal; slow); Troponin I; slow isoform
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-187
  • 氨基酸序列
    PEVERKPKI TASRKLLLKS LMLAKAKECW EQEHEEREAE KVRYLAERIP TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK VMDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTSQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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问答及客户评论

■ 常见问题解答
Q:

I am looking for a full length Human TNNI1 Recombinant Protein.
I saw CSB-EP024011HU on your website.
(1)Is this full length?
(2)Is this in stock? If not available, what is the lead time?
(3)What are the smaller sizes available besides the 500 ug and 1 mg on the website? Kindly provide pricing on the smaller sizes as well.

A:
Thanks for your inquiry. This is a semi-customized protein which have no stock. The smallest size we could provide for CSB-EP024011HU is 500ug. Here we provide the details of four expression systems for your reference.
Recombinant Human Troponin I, slow skeletal muscle(TNNI1)
CSB-YP024011HU >> Yeast
CSB-EP024011HU >> E.coli
CSB-BP024011HU >> Baculovirus
CSB-MP024011HU >> Mammalian cell
Expression Region: 2-187aa; Full Length of Mature Protein
Tag Info: EP, BP, MP: N-terminal 10xHis-tagged and C-terminal Myc-tagged; YP: N-terminal 6xHis-tagged
Expression Sequence:

PEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMDLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGDWRKNVEAM
SGMEGRKKMFDAAKSPTSQ

Q:

We are interested in 1mg of this product:
CSB-YP015535HU: Human NCL Recombinant Protein [Yeast]-1mg
However, we would like the product to be at least 2mg/ml concentration. We know that this would require producing much more protein, because there is loss in concentration. Also, we would like the protein in PBS, no Tris. And any glycerol or BSA below 20%.
What would be the price for a product like this?

A:
Very nice to receive your inquiry. Currently, we have 0.8mg of stock. The concentration is 3mg/ml which can satisfy your requirement.
Here we provide several options for your reference. Please confirm which plan you prefers.
1.You accept our current storage buffer.
Code: CSB-YP015535HU
Delivery Form: Liquid
Storage Buffer: 20 mM Tris-HCl, 0.5 M NaCl, pH 8.0, 50% glycerol
Endotoxin Removal: No
Aseptic Processing: No
2.You insists on their specified buffer (PBS, no Tris, glycerol or BSA below 20%), we could satisfy but have to change the current buffer.
There will be certain loss. Finally we could send 0.5mg . And you decide to purchase 0.5mg instead.
Code: CSB-YP015535HU
Delivery Form: Liquid
Storage Buffer: PBS, no Tris, glycerol or BSA below 20%
Endotoxin Removal: No
Aseptic Processing: No
3. You insist on your specified buffer (PBS, no Tris, glycerol or BSA below 20%), we could satisfy but have to change the current buffer.
There will be certain loss. Finally we could send 0.5mg . If you insist on purchasing 1mg, but could accept two different lots.
Code: CSB-YP015535HU
Delivery Form: Liquid
Storage Buffer: PBS, no Tris, glycerol or BSA below 20%
Endotoxin Removal: No
Aseptic Processing: No
4. You insist on their specified buffer (PBS, no Tris, glycerol or BSA below 20%). You insist on purchasing 1mg, from Same Lot. We have to reproduce a new lot.
Code: CSB-YP015535HU
Delivery Form: Liquid
Storage Buffer: PBS, no Tris, glycerol or BSA below 20%
Endotoxin Removal: No
Aseptic Processing: No
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靶点详情

  • 功能：
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能参考文献：
    1. Ultrasensitive troponin I was detectable in almost all individuals of a study sample reflecting middle-aged to elderly European general population. Ultrasensitive troponin concentrations exhibit an independent, graded, positive relation with incident CHD [coronary heart disease]. PMID: 28585121
    2. Measuring mean platelet volume in conjunction with troponin I levels improves the diagnostic value of troponin I in acute coronary syndrome. PMID: 27524214
    3. CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage. PMID: 26334851
    4. TNNI3K is a cardiac-specific gene, encoding a cardiac troponin I-interacting MAP kinase. In mice, Tnni3k is shown to play an important role in the regulation of cardiac differentiation and cardiac contractility PMID: 25791106
    5. sTnI as a sensitive marker of skeletal muscle injury. PMID: 22323298
    6. Elevations of troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are common in patients with atrial fibrillation and independently related to increased risks of stroke and mortality. PMID: 22374183
    7. Elevated post-operative troponin 1 levels predict long-term mortality in older patients undergoing emergency orthpedic surgery. PMID: 19811558
    8. Evaluated the prevalence of TNN13 gene mutations in sudden death caused by cardiomyopathy (CM); in dilated CM cases, a new missense mutation Pro16Thr was detected. A single nucleotide polymorphism at -8 position of intron 3 was identified. PMID: 20817590
    9. troponin I phosphorylation has a role in protein kinase C-mediated enhanced contractile performance of myocytes PMID: 12815045
    10. MEF2 activation of the troponin I slow enhancer is repressed by hMusTRD1alpha1 PMID: 12857748
    11. Low expression of ssTnI was found in 60% of patients in sinus rhythm or paroxysmal AF and in 8% of patients with chronic AF. Relative ssTnI mRNA expression was significantly lower in patients with AF than in those in sinus rhythm. PMID: 15289369
    12. A biological marker of myocardial injury, but may also be increased after a grand mal seizure. PMID: 15367881
    13. These results suggest that this R21C mutation in TnI affects the Ca(2+)-sensitizing effect of Tn, the ability of TnI to be readily phosphorylated by PKA and the stability of TnI to calpain. PMID: 16005017
    14. Relationship between myocardial injury, assessed by cardiac troponin I (cTnI) levels, and outcome in selected critically ill patients without acute coronary syndromes or cardiac dysfunction PMID: 16236952
    15. This marker in paatients with heart failure and anemia identifies patients at particularly high risk mortality. PMID: 16338262
    16. Increased serum levels of troponin I is associated with calcinosis and coronary Artery Stenosis PMID: 16358990
    17. The plasma levels of CRP and troponin I were also significantly higher in this group of nine patients, and correlated with urinary protein excretion. PMID: 16916777
    18. A revised method of troponin exchange in pemeabilized cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I. PMID: 17051347
    19. a localized N-terminal region of TnI comprised of amino acids 33-80, which interacts with C-terminal regions of cTnC and cTnT, is of particular significance in transducing signaling of thin filament activation by strong cross-bridges PMID: 17099250

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  • 蛋白家族：
    Troponin I family
  • 组织特异性：
    Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.
  • 数据库链接：

    HGNC: 11945

    OMIM: 191042

    KEGG: hsa:7135

    STRING: 9606.ENSP00000337022

    UniGene: Hs.320890

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