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  4. Recombinant Human Trophinin (TRO), partial

Recombinant Human Trophinin (TRO), partial

  • 中文名称：
    人TRO重组蛋白
  • 货号：
    CSB-YP025069HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TRO重组蛋白
  • 货号：
    CSB-EP025069HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TRO重组蛋白
  • 货号：
    CSB-EP025069HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TRO重组蛋白
  • 货号：
    CSB-BP025069HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TRO重组蛋白
  • 货号：
    CSB-MP025069HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TRO
  • Uniprot No.：
    Q12816
  • 别名：
    TRO; KIAA1114; MAGED3; Trophinin; MAGE-D3 antigen
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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TRO antibodies

靶点详情

  • 功能：
    Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.
  • 基因功能参考文献：
    1. Expression of trophinin and dipeptidyl peptidase IV in endometrial co-culture in the presence of an embryo: A comparative immunocytochemical study. PMID: 27035766
    2. report dual roles for trophinin in human cancers in terms of promoting malignancy in some tumor types and suppressing it in others PMID: 22201876
    3. Trophinin induced apoptosis in endometrial epithelial cells through protein kinase C-delta. PMID: 21191175
    4. infertile women with endometriosis or unexplained infertility had significantly weakened trophinin expression in the endometrium in the mid-luteal phase PMID: 12297480
    5. HCG from the human embryo induces trophinin expression by maternal cells. Unique role of hCG and trophinin in human embryo implantation, including the pathogenesis of ectopic pregnancy. PMID: 14633596
    6. Maged3 expression is restricted to the central nervous system where it was mostly detected in postmitotic neurons PMID: 15162511
    7. Fluorescence photobleaching of GFP-trophinin expressed in COS-1 cells showed the stable association of trophinin with the nuclear envelope. PMID: 16288751
    8. trophinin-mediated cell adhesion functions as a molecular switch for trophectoderm activation in human embryo implantation PMID: 17360433
    9. results suggest that trophinin promotes colorectal cancer invasion through a mechanism involving HMGB1/RAGE PMID: 17487845
    10. Trophinin functions as an adhesion molecule on the cell surface and as a molecular switch for trophoblast activation in the cytoplasm. PMID: 17495530
    11. Confocal microscopy analysis of ectopically expressed magphinins revealed that magphinin-alpha and -beta localize in the cytoplasm, whereas magphinin-gamma lacking the peptide encoded by exon-3 is nuclear. PMID: 17559068
    12. When magphinin-gamma was expressed in NIH3T3 cells, cells underwent G1 arrest. These results suggest that human magphinin-gamma inhibits cell cycle progression through nuclear activity. PMID: 17559068
    13. These findings underscore the importance of TRO in tumorigenesis, and suggest that TRO may be a useful biomarker for cisplatin sensitivity and invasive potential. PMID: 17597582
    14. results provide a mechanism for trophinin-mediated adhesion of human blastocyst to endometrium by a spatially and temporally restricted paracrine effect of hCG derived from the blastocyst PMID: 18078818
    15. Overexpression of trophinin leads to a more invasive phenotype and metastatic potential in human gallbladder cancer transfected into nude mice. PMID: 18846386
    16. TROPHONIN (TRO) is among the genes most downregulated by RAS. TRO expression is higher in cisplatin-sensitive cancer cell lines and positively correlates with prognoses in ovarian cancers. PMID: 17597582

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  • 组织特异性：
    Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week
  • 数据库链接：

    HGNC: 12326

    OMIM: 300132

    KEGG: hsa:7216

    STRING: 9606.ENSP00000173898

    UniGene: Hs.633653

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