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  4. Recombinant Human Transmembrane channel-like protein 6 (TMC6), partial

Recombinant Human Transmembrane channel-like protein 6 (TMC6), partial

  • 中文名称：
    人TMC6重组蛋白
  • 货号：
    CSB-YP768764HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TMC6重组蛋白
  • 货号：
    CSB-EP768764HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TMC6重组蛋白
  • 货号：
    CSB-EP768764HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TMC6重组蛋白
  • 货号：
    CSB-BP768764HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TMC6重组蛋白
  • 货号：
    CSB-MP768764HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TMC6
  • Uniprot No.：
    Q7Z403
  • 别名：
    TMC6; EVER1; EVIN1Transmembrane channel-like protein 6; Epidermodysplasia verruciformis protein 1; Protein LAK-4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable ion channel.
  • 基因功能参考文献：
    1. The present study did not show any significant association of the EVER1/2 polymorphisms (rs2290907and rs16970849) with cervical cancer. PMID: 27899077
    2. There were no differences in Ever1 SNPs between head and neck squamous cell carcinoma patients with human papilloma virus (HPV)-positive and HPV-negative tumors, and healthy controls. PMID: 27097911
    3. Findings suggest that SNP in EVER 1 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC tumours that have lost beta-HPV gene expression during progression PMID: 26126409
    4. TMC6/EVER1 and TMC8/EVER2 are known to be involved in the development of EV. PMID: 26227733
    5. TMC6 variants are associated with diminished age-of-onset of P. aeruginosa airway infection in children with cystic fibrosis. PMID: 26047157
    6. EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 or EVER2. PMID: 23534907
    7. Expression of both EVER1 and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB signaling. PMID: 25378492
    8. We report a case of Merkel cell polyomavirus detection in the skin of a patient with epidermodysplasia verruciformis (EDV) and a family history remarkable for an unusual inheritance pattern for EDV. PMID: 23535066
    9. EVER proteins appear as key components of the activation-dependent regulation of Zn(2+) concentration in T cells. However, the impact of EVER-deficiency in T cells on EV pathogenesis remains to be elucidated PMID: 22761942
    10. Data support the involvement of the TMC6/8 region in cervix cancer susceptibility. PMID: 21387292
    11. Mutations in EVER1 are associated with epidermodysplasia verruciformis. PMID: 12426567
    12. Nonsense mutations of EVER1gene is associated with epidermodysplasia verruciformis PMID: 15042430
    13. four mutations in recurrent respiratory papillomatosis patients might indicate that EVER 1 alleles are not associated with susceptibility to RRP PMID: 16487602
    14. The growing number of mutations in epidermodysplasia verruciformis (EV) pedigrees supports the hypothesis that EVER1 and EVER2 are the molecular basis of EV. PMID: 17008061
    15. HPV16 E5 protein binds to EVER and ZnT-1 and blocks their negative regulation PMID: 18158319
    16. epidermodysplasia verruciformis in a father and a son with typical histologic and clinical findings that occur in the absence of mutations in EVER1 PMID: 19706093

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  • 相关疾病：
    Epidermodysplasia verruciformis (EV)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    TMC family
  • 组织特异性：
    Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes.
  • 数据库链接：

    HGNC: 18021

    OMIM: 226400

    KEGG: hsa:11322

    STRING: 9606.ENSP00000313408

    UniGene: Hs.632227

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