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  4. Recombinant Human Tectonin beta-propeller repeat-containing protein 2 (TECPR2), partial

Recombinant Human Tectonin beta-propeller repeat-containing protein 2 (TECPR2), partial

  • 中文名称：
    人TECPR2重组蛋白
  • 货号：
    CSB-YP023369HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TECPR2重组蛋白
  • 货号：
    CSB-EP023369HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TECPR2重组蛋白
  • 货号：
    CSB-EP023369HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TECPR2重组蛋白
  • 货号：
    CSB-BP023369HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TECPR2重组蛋白
  • 货号：
    CSB-MP023369HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TECPR2
  • Uniprot No.：
    O15040
  • 别名：
    TECPR2; KIAA0297; KIAA0329; Tectonin beta-propeller repeat-containing protein 2; WD repeat-containing protein KIAA0329/KIAA0297
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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TECPR2 antibodies

问答及客户评论

■ 常见问题解答
Q:

For this target, we're interested in full length instead of partial. Can you check to see if you can provide this full-length protein? We are interested in 50 ug.

A:
Thanks for your inquiry. The reference link of this protein: https://www.uniprot.org/uniprot/O15040
This full length protein contains 1411aa, which is very difficult to express, the success rate will be much lower even if we agree to have a try, and it's not risk-free.
We can provide custom service if you want to have a try, however as its length is over 800aa, we will charge step by step. The minimum size for EP/YP is 1mg and for BP/MP is 100ug.
If we can successfully express this protein, we will charge some fees accordingly and provide the purified protein.
If we are failed in expressing this protein, you need to pay some fees for the gene synthesis and subcloning, and we will provide the constructed plasmid and strains.
PS: The expression plasmid is not for sale if this project is successful.
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靶点详情

  • 功能：
    Probably plays a role as positive regulator of autophagy.
  • 基因功能参考文献：
    1. Whole exome sequencing in an Italian pedigree suggests involvement of TECPR2 in a complex form of progressive motor neuron disease. PMID: 27406698
    2. The discovery of additional TECPR2 utations in non-Bukharian patients implies that this disease might be more common than previously appreciated PMID: 26542466
    3. Results show that TECPR2 associates with several trafficking components as SEC24D and cooperates with LC3C to regulate ER exit sites and ER export suggesting that TECPR2 functions as molecular scaffold linking early secretion pathway and autophagy. PMID: 26431026
    4. The discovered TECPR2 mutation implicates autophagy, a central intracellular mechanism, in spastic paraparesis. PMID: 23176824
  • 相关疾病：
    Spastic paraplegia 49, autosomal recessive (SPG49)
  • 蛋白家族：
    WD repeat KIAA0329 family
  • 组织特异性：
    Detected in skin fibroblast (at protein level).
  • 数据库链接：

    HGNC: 19957

    OMIM: 615000

    KEGG: hsa:9895

    STRING: 9606.ENSP00000352510

    UniGene: Hs.195667

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