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  4. Recombinant Human THO complex subunit 2 (THOC2), partial

Recombinant Human THO complex subunit 2 (THOC2), partial

  • 中文名称：
    人THOC2重组蛋白
  • 货号：
    CSB-YP818823HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人THOC2重组蛋白
  • 货号：
    CSB-EP818823HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人THOC2重组蛋白
  • 货号：
    CSB-EP818823HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人THOC2重组蛋白
  • 货号：
    CSB-BP818823HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人THOC2重组蛋白
  • 货号：
    CSB-MP818823HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    THOC2
  • Uniprot No.：
    Q8NI27
  • 别名：
    CXorf3; DJ506G2.1; hTREX120; RP5 1189B24.5; THO complex 2; THO complex subunit 2; Tho2; THOC2; THOC2_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development.
  • 基因功能参考文献：
    1. THOC2 mutations implicate mRNA-export pathway in X-linked intellectual disability. PMID: 26166480
    2. recruitment of the human TREX complex to spliced mRNA is not directly coupled to transcription, but is instead coupled to transcription indirectly through splicing PMID: 15998806
  • 相关疾病：
    Mental retardation, X-linked 12 (MRX12)
  • 亚细胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    THOC2 family
  • 组织特异性：
    Expressed in the hippocampus and the cerebral cortex.
  • 数据库链接：

    HGNC: 19073

    OMIM: 300395

    KEGG: hsa:57187

    STRING: 9606.ENSP00000245838

    UniGene: Hs.149991

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