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  4. Recombinant Human Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1), partial

Recombinant Human Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1), partial

  • 中文名称：
    人SVEP1重组蛋白
  • 货号：
    CSB-YP689809HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SVEP1重组蛋白
  • 货号：
    CSB-EP689809HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SVEP1重组蛋白
  • 货号：
    CSB-BP689809HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SVEP1
  • Uniprot No.：
    Q4LDE5
  • 别名：
    C9orf13; CCP module-containing protein 22; CCP22; EGF and pentraxin domain-containing protein 1; Polydom; SEL-OB; Selectin-like osteoblast-derived protein; SELOB; Serologically defined breast cancer antigen NY-BR-38; Sushi; Sushi; von Willebrand factor type A; EGF and pentraxin domain-containing protein 1; SVEP1; SVEP1_HUMAN; von Willebrand factor type A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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SVEP1 Proteins

靶点详情

  • 功能：
    May play a role in the cell attachment process.
  • 基因功能参考文献：
    1. Downregulation of SVEP1 expression in primary keratinocytes resulted in decreased expression of major epidermal differentiation markers. PMID: 27892606
    2. Top association findings suggested that the bipolar disorder risk allele at SNP rs7042161 in SVEP1 gene may be associated with increased risk of essential hypertension. PMID: 27529678
    3. We also found significant associations between coronary artery disease and low-frequency missense variants in the genes SVEP1. PMID: 26934567
    4. c.2080A>C SNP associated with increased 28-day mortality in septic shock PMID: 25188548
    5. polydom is a hitherto unknown ligand for integrin alpha9beta1 that functions as a physiological ligand in vivo. PMID: 22654117
    6. Increased UT-II, sTM, and vWF in ankylosing spondylitis patient sera regardless of treatment and disease activity suggest an increased tendency for atherosclerosis. PMID: 21556780
    7. acts as regulator of ICAM1 and E-selectin during endotoxemia PMID: 20236627
    8. All together makes SEL-OB/SVEP1 an attractive marker for studying the role of stromal osteogenic cells and their interactions within the bone marrow microenvironment creating a network that regulates the skeletal homeostasis. PMID: 16206243

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  • 亚细胞定位：
    Secreted. Cytoplasm. Membrane; Peripheral membrane protein.
  • 组织特异性：
    Present in mesenchymal primary cultured cell lysates (at protein level). Highly expressed in placenta. Also expressed in marrow stromal cell. Weakly or not expressed in other tissues.
  • 数据库链接：

    HGNC: 15985

    OMIM: 611691

    KEGG: hsa:79987

    STRING: 9606.ENSP00000384917

    UniGene: Hs.522334

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