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  4. Recombinant Human Structural maintenance of chromosomes protein 1B (SMC1B), partial

Recombinant Human Structural maintenance of chromosomes protein 1B (SMC1B), partial

  • 中文名称：
    人SMC1B重组蛋白
  • 货号：
    CSB-YP854104HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SMC1B重组蛋白
  • 货号：
    CSB-EP854104HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SMC1B重组蛋白
  • 货号：
    CSB-EP854104HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SMC1B重组蛋白
  • 货号：
    CSB-BP854104HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SMC1B重组蛋白
  • 货号：
    CSB-MP854104HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SMC1B
  • Uniprot No.：
    Q8NDV3
  • 别名：
    bK268H5; SMC protein 1B; SMC-1-beta; SMC-1B; SMC1 beta; SMC1B; SMC1B_HUMAN; SMC1beta; SMC1beta protein; Smc1l2; Structural maintenance of chromosomes 1-like 2; Structural maintenance of chromosomes 1B; Structural maintenance of chromosomes protein 1B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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SMC1B antibodies

靶点详情

  • 功能：
    Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
  • 基因功能参考文献：
    1. Through the translational regulation of novel RNA targets SMC1B and TEX11, DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility. PMID: 28364521
    2. Data show that structural maintenance of chromosomes protein 1B (SMC1B) is expressed in primary fibroblasts. PMID: 26673124
    3. High SMC1B expression is associated with pancreatic cancer. PMID: 25216700
  • 亚细胞定位：
    Nucleus. Chromosome. Chromosome, centromere.
  • 蛋白家族：
    SMC family, SMC1 subfamily
  • 数据库链接：

    HGNC: 11112

    OMIM: 608685

    KEGG: hsa:27127

    STRING: 9606.ENSP00000350036

    UniGene: Hs.334176

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