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  4. Recombinant Human Stabilin-1 (STAB1), partial

Recombinant Human Stabilin-1 (STAB1), partial

In Stock
  • 中文名称：
    人STAB1重组蛋白
  • 货号：
    CSB-EP865173HU
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    STAB1
  • Uniprot No.：
    Q9NY15
  • 别名：
    (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1)(FEEL-1)(MS-1 antigen)
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    22.7
  • 表达区域：
    2319-2462aa
  • 氨基酸序列
    STCNGKLLDVLAATANFSTFYGMLLGYANATQRGLDFLDFLDDELTYKTLFVPVNEGFVDNMTLSGPDLELHASNATLLSANASQGKLLPAHSGLSLIISDAGPDNSSWAPVAPGTVVVSRIIVWDIMAFNGIIHALASPLLAP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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STAB1 antibodies

STAB1 Proteins

靶点详情

  • 功能：
    Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
  • 基因功能参考文献：
    1. Satb1 promotes osteoclastogenesis by recruiting CREB-binding protein to upregulate miR-223 expression in chronic kidney disease-mineral and bone disorder PMID: 29442043
    2. Systemic rAAV-DCN in neuroblastoma-grafted nude mice inhibited stabilin-1. PMID: 28631095
    3. Results suggest stabilin-1 mediated silent clearance of extracellular tumor growth-inhibiting factors as a mechanism of stabilin-1 induced tumor growth. PMID: 27105498
    4. These data define stabilin-1 as a new immunosuppressive molecule and suggest that stabilin-1(high) monocytes may dampen proinflammatory reactions in vivo. PMID: 26608916
    5. The present findings suggest that STAB1 is a new and highly promising candidate gene in this region. The combining of gene expression and GWAS data may provide valuable insights into the biological mechanisms of BD. PMID: 25136889
    6. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14 PMID: 23670221
    7. The associations between CLEVER-1 expression on endothelial vessels and macrophage/leukocyte infiltration is suggestive of its regulation by inflammatory conditions in breast cancer, most likely by macrophage-associated cytokines. PMID: 21483103
    8. macrophage stabilin-1/CLEVER-1 can potentially regulate leukocyte migration and scavenging during the development of the placenta and fetus PMID: 21480214
    9. Studies identified a binding site on SPARC for stabilin-1 by a solid-state peptide array coupled with a modified enzyme-linked immunosorbent assay. PMID: 21308731
    10. CLEVER-1/stabilin-1 can support lymphocyte transendothelial migration; it also may provide an organ-specific signal for regulatory T cell recruitment to the inflamed liver and to hepatocellular carcinoma. PMID: 21368224
    11. Studies shoe that understanding stabilin-1 behavior in complex biological systems and would open perspectives for therapeutic targeting of stabilin-1 pathways in chronic inflammation. PMID: 20953554
    12. these results indicate that GULP functions as an adaptor protein for stabilin-1-mediated phagocytosis. PMID: 20599701
    13. role in endocytic clearance and secretion in macrophages; review PMID: 19457577
    14. code for homologous transmembrane proteins featuring seven fasciclin-like adhesion domains, 18-20 epidermal-growth-factor domains, one X-link domain and three to six B-(X(7))-B hyaluronan-binding motifs PMID: 11829752
    15. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. PMID: 12077138
    16. This and FEEL-2 are endocytic receptors for advanced glycation end products. PMID: 12473645
    17. CLEVER-1 also known as stabilin-1 or FEEL-1) is a large multifunctional glycoprotein implicated in scavenging, angiogenesis, cell adhesion and angiogenesis PMID: 15297319
    18. role for stabilin-1 as a rapidly recycling scavenger receptor PMID: 15345716
    19. stabilin-1 may function in endocytic and secretory processes of human macrophages. PMID: 15345724
    20. Stabilin-1 internalizes and targets secreted protein acidic and rich in cysteine (SPARC) to an endosomal pathway in stably transfected Chinese hamster ovary cells. PMID: 16670288
    21. Stabilin-1 mediates internalization and endosomal sorting of placental lactogen. PMID: 18292525
    22. Stabilin-1, found on alternatively activated macrophages, is a phagocytic receptor mediating the clearance of apoptotic cells in a phosphatidylserine-dependent manner. PMID: 19726632
    23. The novel GGA-binding site EDDADDD is essential for stabilin-1-mediated intracellular sorting but is not required for endocytosis. PMID: 19752197

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.
  • 数据库链接：

    HGNC: 18628

    OMIM: 608560

    KEGG: hsa:23166

    STRING: 9606.ENSP00000312946

    UniGene: Hs.301989

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