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  4. Recombinant Human Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8), partial

Recombinant Human Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8), partial

  • 中文名称：
    人SLC2A8重组蛋白
  • 货号：
    CSB-YP882139HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC2A8重组蛋白
  • 货号：
    CSB-EP882139HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC2A8重组蛋白
  • 货号：
    CSB-EP882139HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC2A8重组蛋白
  • 货号：
    CSB-BP882139HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC2A8重组蛋白
  • 货号：
    CSB-MP882139HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC2A8
  • Uniprot No.：
    Q9NY64
  • 别名：
    SLC2A8; GLUT8; GLUTX1; Solute carrier family 2; facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.
  • 基因功能参考文献：
    1. Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction PMID: 29590129
    2. these data suggest that cytoplasmic trehalose access is carrier-mediated, and that GLUT8 is a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction. PMID: 27922102
    3. glucose/fructose is transported into the cytoplasm of vimentin- or GFAP-positive astrocytic and CD68- or HLA-DR-positive microglial cells located around the lateral ventricle PMID: 27818355
    4. The findings support the hypothesis of the transport of intravascularGLUT8 through the epithelial cells of the choroid plexus and the ependymal cells. PMID: 27160096
    5. GLUT8 is thus essential for hepatocyte fructose transport and fructose-induced macrosteatosis. PMID: 24519932
    6. SLC2A8 is upregulated in fast progressing Alzheimer's disease patients, compared to slow progressors. PMID: 23234877
    7. Critical roles for novel GLUT family members highlight a therapeutic strategy entailing selective GLUT inhibition to specifically target aberrant glucose metabolism in cancer. PMID: 22452979
    8. This carrier protein is expressed in human tissues of the testis in a gonadotropin-dependent manner. PMID: 11845330
    9. The recruitment of GLUT8 to the endocytic machinery occurs via direct interaction of the dileucine motif with beta2-adaptin, and that endocytosis might be the main site at which GLUT8 is likely to be regulated. PMID: 16723738
    10. The expression pattern of GLUT8 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry. PMID: 19554504

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
  • 组织特异性：
    Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.
  • 数据库链接：

    HGNC: 13812

    OMIM: 605245

    KEGG: hsa:29988

    STRING: 9606.ENSP00000362469

    UniGene: Hs.179522

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