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  4. Recombinant Human Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12), partial

Recombinant Human Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12), partial

  • 中文名称：
    人SLC2A12重组蛋白
  • 货号：
    CSB-YP848405HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC2A12重组蛋白
  • 货号：
    CSB-EP848405HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC2A12重组蛋白
  • 货号：
    CSB-EP848405HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC2A12重组蛋白
  • 货号：
    CSB-BP848405HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC2A12重组蛋白
  • 货号：
    CSB-MP848405HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC2A12
  • Uniprot No.：
    Q8TD20
  • 别名：
    Glucose transporter type 12; GLUT 12; GLUT-12; GLUT12; GLUT8; GTR12_HUMAN; SLC2A12; Solute carrier family 2 (facilitated glucose transporter) member 12; Solute carrier family 2 facilitated glucose transporter member 12; Solute carrier family 2 member 12; Solute carrier family 2, facilitated glucose transporter member 12
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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SLC2A12 antibodies

靶点详情

  • 功能：
    Insulin-independent facilitative glucose transporter.
  • 基因功能参考文献：
    1. GLUT12-knockdown completely abrogated high glucose-induced migration, indicating that GLUT12 functionally participates in sensing high glucose concentrations. PMID: 29187448
    2. GLUT12 is a versatile transporter: it transports a wide diversity of hexoses, it can work as a Na+ or H+/glucose symporter, and it shows electrogenic properties. PMID: 25855082
    3. findings show the level of expression of GLUT12 was significantly higher in Alzheimer's disease compare to aged controls PMID: 24820014
    4. Intestinal dehydroascorbic acid (DHA) transport is mediated by the facilitative sugar transporters, GLUT2 and GLUT8 PMID: 23396969
    5. Embedded in microvillous (maternal-facing) and basal (fetal-facing) membranes of syncytiotrophoblast, main placental barrier layer. (review) PMID: 12583599
    6. Glucose transport properties and hexose affinities of GLUT12. PMID: 12914765
    7. GLUT12 protein was localized to the apical membrane of human and rat distal tubules and collecting ducts. Levels of both GLUT1 and GLUT12 are elevated in animal models of hypertension and diabetic nephropathy. PMID: 16091581
    8. GLUT4 and GLUT12 were predominantly expressed in type I oxidative fibers; however, GLUT5 was expressed predominantly in type II (white) fibers PMID: 16803853
    9. Translocation of GLUT12 in cultured myoblasts was dependent on activation of PI3-K. PMID: 19549745

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
  • 组织特异性：
    Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney.
  • 数据库链接：

    HGNC: 18067

    OMIM: 610372

    KEGG: hsa:154091

    STRING: 9606.ENSP00000275230

    UniGene: Hs.486508

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