Recombinant Human Solute carrier family 12 member 2 (SLC12A2), partial

1. NKCC1 not only controls cell volume and Cl- concentration, but it can also regulate the actin cytoskeleton through Cofilin 1. PMID: 28679472
2. This new functional assay offered a robust working model for NKCC1 in determining reliable and concordant rank orders of the test compounds supporting its sensitivity and specificity. PMID: 28631939
3. we introduce the molecular mechanism by which flavonoids, specifically quercetin, act through elevation of [Cl(-) ]c via activation of NKCC1 on important factors controlling various body and cellular functions, such as (1) antihypertensive actions controlling blood volume dependent on the amounts of renal Na(+) reabsorption via expression of the epithelial Na(+) channel PMID: 28574574
4. NKCC1 and KCCs are coordinately regulated by L-WNK1 isoforms. PMID: 27170636
5. NKCC1 high expression predicted a bad clinical outcome for lung adenocarcinoma patients and EGFR-mutated subgroup. Therefore, NKCC1 may play a role in lung adenocarcinoma and novel therapeutic tactics could be developed by targeting NKCC1 protein. PMID: 26559081
6. Study describes a functional missense variant in SLC12A2 in human schizophrenia, and suggest that genetically encoded dysregulation of NKCC1 may be a risk factor for, or contribute to the pathogenesis of, schizophrenia PMID: 26955005
7. The NKCC-1 is a Na(+)- dependent Cl(-) transporter that mediates the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane and maintains cell volume and intracellular K(+) and Cl(-) homeostasis. PMID: 25620102
8. NKCC1 labeling was seen only in the basolateral membrane of the secretory coils. PMID: 25218052
9. Suggest that the expression of NKCC1 in esophageal squamous cell carcinoma may affect the G2/M checkpoint and may be related to the degree of histological differentiation of SCCs. PMID: 24944475
10. Functional expression of human NKCC1 from a synthetic cassette-based cDNA: introduction of extracellular epitope tags and removal of cysteines. PMID: 24339991
11. our data show a novel role for the WNK1/OSR1/NKCC1 pathway in glioma migration PMID: 24555568
12. NKCC activation involves movement of TM12 relative to TM10, which is likely tied to movement of the large C terminus PMID: 24451383
13. Reduced KCC2/NKCC1 ratio in the cerebrospinal fluid of Rett Syndrome patients suggests a disturbed process of GABAergic neuronal maturation and open up a new therapeutic perspective. PMID: 23894354
14. The hormone aldosterone was found to upregulate NKCC1 by increasing protein stability. PMID: 24173102
15. The rs10089 single nucleotide polymorphism was associated with increased susceptibility to noise-induced hearing loss. PMID: 23224734
16. Altered hippocampal area function and coupling in DISC1 and SLC12A2 minor allele carriers. PMID: 23921125
17. The results indicate a role for COMMD1 in the regulation of NKCC1 membrane expression and ubiquitination. PMID: 23515529
18. These findings suggest that NKCC1 and AQP1 participate in meningioma biology and invasion PMID: 23317544
19. A significant association is found between single nucleotide polymophisms in SLC12A2 and CTXN3 and schizophrenia in a Thai population. PMID: 22643131
20. Capsaicin inhibits chloride secretion in part by causing NKCC1 internalization, but by a mechanism that appears to be independent of TRPV1. PMID: 23139219
21. NKCC1 deficiency increases the size of focal adhesions. PMID: 22570591
22. predictions of homology models of NKCC1 and demonstrate important roles for TM3 residues in ion translocation and loop diuretic inhibition. PMID: 22437837
23. NKCC1 plays an important and yet partial role in RVI in C-20/A4 chondrocytes. PMID: 21847667
24. The coupling between salt and water transport in NKCC1 represents a novel aspect of cellular water homeostasis where cells can change their volume independently of the direction of an osmotic gradient across the membrane. PMID: 20819947
25. phosphorylation-induced activation of NKCC1 by osmotic shrinkage does not involve AMP-activated protein kinase and is likely to be due to STE20/SPS1-related proline/alanine-rich kinase activation PMID: 20442269
26. The result points at secretion as the main mechanism of cyst filling, and NKCC1 as the key candidate of fluid transport. PMID: 20471979
27. decreased NKCC1 may contribute to the feature of the pathogenesis of salt-sensitive hypertension seen in African Americans. PMID: 20044742
28. NKCC1 modulates blood pressure through vascular and renal effects--REVIEW PMID: 20061948
29. NKCC1 mRNA is expressed predominately in small- and medium-diameter primary afferent neurons,21 and the NKCC1 population of sensory neurons includes a large proportion that express TrpV1 and thus are presumably capsaicin-sensitive nociceptorscu PMID: 19916249
30. NKCC1 was found in human HuH-7 hepatoma cells. The data suggest a role of NKCC1 in stellate cell transformation, hepatic volume regulation, and long-term adaption to dehydrating conditions. PMID: 12054469
31. most CFTR-positive ADPKD cysts also express NKCC1 suggests that transepithelial Cl(-) secretion in ADPKD involves molecular mechanisms similar to secretory epithelia. PMID: 12355171
32. all of the CCCs examined (NKCC1, NKCC2, KCC1, KCC3, and KCC4) can promote NH4(+) translocation, presumably through binding of the ion at the K(+) site PMID: 12657561
33. data conclusively link PASK with the phosphorylation and activation of NKCC1 PMID: 12740379
34. the stimulation of either luminal or basolateral P2R increased NKCC1 activity, which was observed in the basolateral membrane, but not in the luminal membrane PMID: 14982922
35. the uncovered interacting domains are probably a major determinant of the NKCC1 conformational landscape PMID: 15280386
36. Data indicate that binding of hsp90 to the Na(+)-K(+)-Cl(-) cotransporter (NKCC1) may be required for sodium-potassium-chloride cotransport to occur at the cell surface. PMID: 15347682
37. role of the complex of serine/threonine protein kinases and a protein phosphatase is probably the maintenance of optimal phosphorylation of NKCC1 coincident with its physiological function in epithelial absorption and secretion PMID: 15899883
38. Taken together, the results of the present study indicate that the signal transduction protein, controlled by the Na+/K+/Cl- cotransporter, must be downstream of the PKC, and at/or upstream to MEK in the Ras/Raf/MEK/ERK cascade. PMID: 16222701
39. NKCC1 transporter facilitates seizures in the developing brain. PMID: 16227993
40. persistent NKCC1 activation by cAMP is constrained by a Ca(2+)-dependent cycle of co-transporter internalization, degradation and re-expression; this is a novel mechanism to limit intestinal fluid loss. PMID: 17478539
41. Ammonium was transported on NKCC1 in T84 cells nearly as well as potassium PMID: 18032481
42. Reveal a novel role for the EGFR in the chronic regulation of epithelial secretory capacity through upregulation of NKCC1 expression. PMID: 18400987
43. membrane rafts render KCC2 inactive and NKCC1 active PMID: 19686239

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HGNC: 10911

OMIM: 600840

KEGG: hsa:6558

STRING: 9606.ENSP00000262461

UniGene: Hs.162585