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  4. Recombinant Human Sodium/hydrogen exchanger 2 (SLC9A2), partial

Recombinant Human Sodium/hydrogen exchanger 2 (SLC9A2), partial

  • 中文名称：
    人SLC9A2重组蛋白
  • 货号：
    CSB-YP887011HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC9A2重组蛋白
  • 货号：
    CSB-EP887011HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC9A2重组蛋白
  • 货号：
    CSB-EP887011HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC9A2重组蛋白
  • 货号：
    CSB-BP887011HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC9A2重组蛋白
  • 货号：
    CSB-MP887011HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC9A2
  • Uniprot No.：
    Q9UBY0
  • 别名：
    H7; Na(+)/H(+) exchanger 2; NHE 2; NHE-2; NHE2; SL9A2_HUMAN; Slc9a2; Sodium/hydrogen exchanger; Sodium/hydrogen exchanger 2; Solute carrier family 9 (sodium/hydrogen exchanger), member 2; Solute carrier family 9 member 2; Solute carrier family 9, member 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.
  • 基因功能参考文献：
    1. Studies show that phosphorylation of the NHE3 at a single amino acid in the distal part of the C-terminus affects multiple aspects of NHE3 complex formation and changes the NHE3 lipid raft distribution, which cause changes in specific aspects of basal as well as acutely stimulated and inhibited Na(+)/H(+) exchange activity. PMID: 28495796
    2. These data indicate that the acid-dependent NHE2 stimulation is implemented by transcriptional upregulation of NHE2 via acid-induced Egr-1 in the intestinal epithelial cells. PMID: 24376510
    3. In humans, NHE2 transcripts appear to be gestationally regulated, which may contribute to changes in NHE activity. PMID: 15664417
    4. expression of the human NHE2 promoter is controlled by Sp1 and Sp3 by interactions with the proximal promoter and the transcription initiation site of NHE2 PMID: 17561809
    5. No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA. PMID: 17881426
    6. Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cells. PMID: 19056765
    7. Report morphological adaptation with preserved proliferation/NHE2 content in the colon of patients with short bowel syndrome. PMID: 19389806

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
  • 组织特异性：
    Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.
  • 数据库链接：

    HGNC: 11072

    OMIM: 600530

    KEGG: hsa:6549

    STRING: 9606.ENSP00000233969

    UniGene: Hs.250083

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