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  4. Recombinant Human Sodium- and chloride-dependent glycine transporter 1 (SLC6A9), partial

Recombinant Human Sodium- and chloride-dependent glycine transporter 1 (SLC6A9), partial

  • 中文名称：
    人SLC6A9重组蛋白
  • 货号：
    CSB-YP021708HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC6A9重组蛋白
  • 货号：
    CSB-EP021708HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC6A9重组蛋白
  • 货号：
    CSB-EP021708HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC6A9重组蛋白
  • 货号：
    CSB-BP021708HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC6A9重组蛋白
  • 货号：
    CSB-MP021708HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC6A9
  • Uniprot No.：
    P48067
  • 别名：
    glycine transporter 1; Glyt 1; GlyT-1; GlyT1; SC6A9_HUMAN; SLC6A9; Sodium and chloride dependent glycine transporter 1; Sodium- and chloride-dependent glycine transporter 1; Solute carrier family 6 member 9
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
  • 基因功能参考文献：
    1. Whole-exome sequencing revealed a novel homozygous missense variant in exon 9 of SLC6A9 NM_201649.3: c.1219 A>G (p.Ser407Gly) that segregates with the disease within the family. In murine model, knockout of Slc6a9 is associated with equivalent phenotype of non-ketotic hyperglycinemia (NKH), namely respiratory distress and hypotonia. PMID: 27481395
    2. This study demonstrates that lack of GLYT1 leads to a distinct human neurological syndrome hallmarked by mildly elevated cerebrospinal fluid glycine and normal serum glycine. PMID: 27773429
    3. Study found that temporal lobe epilepsy is associated with increased levels of GlyT1 PMID: 26302655
    4. Following biopterin administration, glycine transporter type I occupancy correlates with biopterin plasma concentration. PMID: 23132267
    5. The increased sensitivity of human GlyT1c to sanguinarine is abolished by the mutation of only cysteine 475. PMID: 22705056
    6. Human positron-emission tomography studies determine the test-retest reproducibility of [11C]GSK931145, a ligand which readily enters the brain, displaying a heterogeneous uptake which corresponds well with the known distribution of GlyT-1. PMID: 21688322
    7. Synaptic and extrasynaptic concentrations of glycine are regulated by its type-1 glycine transporter, which is primarily expressed in astroglial and glutamatergic cell membranes. PMID: 22425803
    8. metabolic functions of GLYT1 in intestine: metabolism/regulation of glycine/glutathione; role in response to physiological stress (e.g., oxidative stress); possible role in pathophysiology/therapy of inflammatory bowel diseases [REVIEW] PMID: 21628872
    9. The mechanism of allosteric interaction of cytoplasmic and extracellular Cl- in the glial glycine transporter (hGlyTlb). PMID: 16121932
    10. Genetic variation of the glycine transporter 1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis. PMID: 17582620
    11. Single nucleotide polymorphism or haplotype of the gene produce risks for susceptibility to drug dependence. PMID: 18411704
    12. SLC6A9 gene is associated with schizophrenia. PMID: 18638388
    13. the results suggest that GLYT1 and membrane rafts are co-localized in the membrane, and that this influences the rate of glycine transport. PMID: 19427831
    14. association between SLC6A9 SNPs and essential hypertension in a Japanese population, suggesting that SLC6A9 is a susceptibility locus for essential hypertension. PMID: 19556729

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  • 相关疾病：
    Glycine encephalopathy with normal serum glycine (GCENSG)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A9 subfamily
  • 组织特异性：
    Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.
  • 数据库链接：

    HGNC: 11056

    OMIM: 601019

    KEGG: hsa:6536

    STRING: 9606.ENSP00000353791

    UniGene: Hs.442590

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