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  4. Recombinant Human Smoothelin (SMTN), partial

Recombinant Human Smoothelin (SMTN), partial

  • 中文名称：
    人SMTN重组蛋白
  • 货号：
    CSB-YP021855HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SMTN重组蛋白
  • 货号：
    CSB-EP021855HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SMTN重组蛋白
  • 货号：
    CSB-EP021855HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SMTN重组蛋白
  • 货号：
    CSB-BP021855HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SMTN重组蛋白
  • 货号：
    CSB-MP021855HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SMTN
  • Uniprot No.：
    P53814
  • 别名：
    FLJ35168; FLJ35365; FLJ35620; FLJ38597; Smoothelin; SMSMO; Smtn; SMTN_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Structural protein of the cytoskeleton.
  • 基因功能参考文献：
    1. Smoothelin is a specific marker for smooth muscle cells with contractile capacity which has not been widely studied in glomus lesions. in this study, glomic cells showed cytoplasmic positivity for smoothelin. Smoothelin expression in glomic cells indicates that they are contractile smooth muscle cells, and thus its role in routine diagnosis should be considered. PMID: 27184662
    2. Caldesmon and smoothelin staining allows better delineation of the muscularis propria from the desmoplastic stromal reaction which provides a critical aide for proper staging of colonic adenocarcinomas. PMID: 24551305
    3. During development of advanced liver fibrosis, a subpopulation of myofibroblasts expressing smoothelin may be derived from vascular smooth muscle cells. PMID: 24409061
    4. lower level of expresseion in colonic inertia patients PMID: 23060305
    5. The objective of the following study was to record the specificity and sensitivity of alpha5(IV) loss, smoothelin expression and PLAP expression as markers of gastrointestinal smooth muscle neoplasms PMID: 24043717
    6. There is an association between essential hypertension and the SMTN gene. PMID: 23121329
    7. Phenotypic expression of alpha-smooth muscle actin, smooth muscle myosin heavy chain 2, and smoothelin were significantly decreased in the dissected media, whereas that of osteopontin was elevated. PMID: 22960022
    8. Smoothelin haplotype constructed using rs5997872, rs56095120, rs9621187 and rs10304 was a useful genetic marker of cerebral infarction in Japanese men. PMID: 23033319
    9. for the Japanese women, the frequency of the C-T-T-G haplotype (established by rs5997872, rs56095120, rs9621187, and rs10304) was significantly higher in the myocardial infarction group than in the control group PMID: 22963604
    10. Smoothelin immunoreactivity in bladder diverticula confirms limited nature of smoothelin expression in muscularis mucosae and represents useful ancillary technique in proper histopathologic evaluation of diverticular and nondiverticular bladder carcinoma PMID: 21683983
    11. We report the first study of smoothelin expression in normal skin PMID: 21472682
    12. Immunohistochemistry for smoothelin identifies differential staining between the neomuscularis mucosa and the true muscularis mucosa in Barrett's esophagus. PMID: 21164287
    13. The expression of smoothelin was analysed immunohistochemically in comparison with alpha-smooth muscle actin (alpha-SMA) in specimens from colon, stomach and oesophagus (n = 107). PMID: 20716166
    14. Smoothelin immunohistochemistry has diagnostic utility in the evaluation of muscularis propria invasion in urothelial carcinoma. PMID: 20636795
    15. Confirm the relatively distinct staining pattern of smoothelin between muscularis mucosae and muscularis propria and suggest caution when using smoothelin immunohistochemistry as a diagnostic tool. PMID: 20154589
    16. immunohistochemistry, using a panel composed of desmin, smoothelin, and vimentin, may be potentially useful for staging of bladder carcinoma. PMID: 19252475
    17. Suggest that the extent and pattern of smoothelin expression may help differentiate between benign and malignant mesenchymal tumors of the GI tract. PMID: 19950405

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Note=Exhibits a filamentous organization.
  • 蛋白家族：
    Smoothelin family
  • 组织特异性：
    Smooth muscle; contractile or vascular (for the long form).
  • 数据库链接：

    HGNC: 11126

    OMIM: 602127

    KEGG: hsa:6525

    STRING: 9606.ENSP00000351593

    UniGene: Hs.149098

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