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  4. Recombinant Human Sialic acid-binding Ig-like lectin 11 (SIGLEC11), partial

Recombinant Human Sialic acid-binding Ig-like lectin 11 (SIGLEC11), partial

  • 中文名称：
    人SIGLEC11重组蛋白
  • 货号：
    CSB-YP836293HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SIGLEC11重组蛋白
  • 货号：
    CSB-EP836293HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SIGLEC11重组蛋白
  • 货号：
    CSB-EP836293HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SIGLEC11重组蛋白
  • 货号：
    CSB-BP836293HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SIGLEC11重组蛋白
  • 货号：
    CSB-MP836293HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SIGLEC11
  • Uniprot No.：
    Q96RL6
  • 别名：
    sialic acid binding Ig like lectin 11; sialic acid binding lectin 11; Sialic acid-binding Ig-like lectin 11; Sialic acid-binding lectin 11; SIG11_HUMAN; Siglec 11; Siglec-11; SIGLEC11
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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SIGLEC11 antibodies

靶点详情

  • 功能：
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
  • 基因功能参考文献：
    1. The authors demonstrated that the human-specific pathogen Escherichia coli K1 uses its polysialic acid capsule as a molecular mimic to engage Siglec-11 and escape killing. In contrast, engagement of the activating counterpart Siglec-16 increases elimination of bacteria. PMID: 28100677
    2. The results indicate potential roles for Siglec-11 in ovarian physiology and human evolution. PMID: 21467073
    3. Siglec-11 ectopically expressed on murine microglia interacts with PSA on neurons, reduces LPS-induced gene transcription of proinflammatory mediators, impairs phagocytosis and alleviates microglial neurotoxicity. PMID: 20203208
    4. cloning and characterization; a recently evolved signaling that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages including brain microglia PMID: 11986327
    5. expressed in human but not in chimpanzee brain microglia; findings indicate that human SIGLEC11 emerged through human-specific gene conversion by an adjacent pseudogene PMID: 16151003
    6. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. PMID: 18629938

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 组织特异性：
    Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
  • 数据库链接：

    HGNC: 15622

    OMIM: 607157

    KEGG: hsa:114132

    STRING: 9606.ENSP00000412361

    UniGene: Hs.661852

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