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  4. Recombinant Human Shugoshin-like 2 (SGOL2), partial

Recombinant Human Shugoshin-like 2 (SGOL2), partial

  • 中文名称：
    人SGO2重组蛋白
  • 货号：
    CSB-YP690897HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SGO2重组蛋白
  • 货号：
    CSB-EP690897HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SGO2重组蛋白
  • 货号：
    CSB-EP690897HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SGO2重组蛋白
  • 货号：
    CSB-BP690897HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SGO2重组蛋白
  • 货号：
    CSB-MP690897HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SGO2
  • Uniprot No.：
    Q562F6
  • 别名：
    Sgo2; Sgol2; SGOL2_HUMAN; Shugoshin-2; Shugoshin-like 2; Tripin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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SGO2 antibodies

靶点详情

  • 功能：
    Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.
  • 基因功能参考文献：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that SGO2 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. Molecular chaperone SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression. PMID: 28781233
    3. In mouse, Sgol2a encoding shugoshin-like 2a is necessary during meiosis in both sexes to maintain the integrity of the cohesin complex that tethers sister chromatids. Human SGO2 has not previously been implicated in any disorder, but in this case of POI and perhaps others, it is a candidate for unexplained infertility PMID: 27629923
    4. Sgol2's ability to protect cohesin depends on its interaction with PP2A, as is its ability to silence the SAC, with the latter being mediated by direct binding to Mad2 PMID: 24192037
    5. identified the phosphorylation of hSgo2 by Aurora B at the N-terminal coiled-coil region and the middle region, and showed that these phosphorylations separately promote binding of hSgo2 to PP2A and MCAK PMID: 20889715

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  • 亚细胞定位：
    Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    Shugoshin family
  • 数据库链接：

    HGNC: 30812

    OMIM: 612425

    KEGG: hsa:151246

    STRING: 9606.ENSP00000350447

    UniGene: Hs.655182

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