Recombinant Human Serine/threonine-protein phosphatase 2A regulatory subunit B' subunit gamma (PPP2R3C)

中文名称：

人PPP2R3C重组蛋白
货号：

CSB-YP836171HU
规格：
来源：

Yeast
其他：

中文名称：

人PPP2R3C重组蛋白
货号：

CSB-EP836171HU-B
规格：
来源：

E.coli
共轭：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名称：

人PPP2R3C重组蛋白
货号：

CSB-BP836171HU
规格：
来源：

Baculovirus
其他：

中文名称：

人PPP2R3C重组蛋白
货号：

CSB-MP836171HU
规格：
来源：

Mammalian cell
其他：

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纯度：

>85% (SDS-PAGE)
基因名：

PPP2R3C
Uniprot No.：

Q969Q6
别名：

C14orf10; Chromosome 14 open reading frame 10; G4-1; G5pr; Hypothetical protein FLJ20644; P2R3C_HUMAN; ppp2r3c; protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma; Protein phosphatase 2 regulatory subunit B''gamma; protein phosphatase 2, regulatory subunit B'', gamma; Protein phosphatase subunit G5PR; rhabdomyosarcoma antigen MU-RMS-40.6A; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C; rhabdomyosarcoma antigen Mu-RMS-40.6C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
种属：

Homo sapiens (Human)
蛋白长度：

full length protein
表达区域：

1-453
氨基酸序列

MDWKEVLRRR LATPNTCPNK KKSEQELKDE EMDLFTKYYS EWKGGRKNTN EFYKTIPRFY YRLPAEDEVL LQKLREESRA VFLQRKSREL LDNEELQNLW FLLDKHQTPP MIGEEAMINY ENFLKVGEKA GAKCKQFFTA KVFAKLLHTD SYGRISIMQF FNYVMRKVWL HQTRIGLSLY DVAGQGYLRE SDLENYILEL IPTLPQLDGL EKSFYSFYVC TAVRKFFFFL DPLRTGKIKI QDILACSFLD DLLELRDEEL SKESQETNWF SAPSALRVYG QYLNLDKDHN GMLSKEELSR YGTATMTNVF LDRVFQECLT YDGEMDYKTY LDFVLALENR KEPAALQYIF KLLDIENKGY LNVFSLNYFF RAIQELMKIH GQDPVSFQDV KDEIFDMVKP KDPLKISLQD LINSNQGDTV TTILIDLNGF WTYENREALV ANDSENSADL DDT
蛋白标签：

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
产品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

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功能：

May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.
基因功能参考文献：
1. Knockdown of PP5 and/or PPP2R3C increased P-gp expression and lowered the sensitivity to vincristine and doxorubicin. Consequently, results indicate that PP5/PPP2R3C negatively regulates P-gp expression and function. PMID: 24333728
2. G5PR expression is markedly augmented in the centrocytes of germinal centers after immunization of transgenic mice with T cell-dependent antigen. PMID: 22753944
亚细胞定位：

Nucleus. Cytoplasm.
组织特异性：

Ubiquitously expressed in brain and other tissues.
数据库链接：

HGNC: 17485

OMIM: 615902

KEGG: hsa:55012

STRING: 9606.ENSP00000261475

UniGene: Hs.530712

Recombinant Human Serine/threonine-protein phosphatase 2A regulatory subunit B' subunit gamma (PPP2R3C)

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