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  4. Recombinant Human Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10), partial

Recombinant Human Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10), partial

  • 中文名称：
    人PPP1R10重组蛋白
  • 货号：
    CSB-YP836284HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PPP1R10重组蛋白
  • 货号：
    CSB-EP836284HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PPP1R10重组蛋白
  • 货号：
    CSB-EP836284HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PPP1R10重组蛋白
  • 货号：
    CSB-BP836284HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PPP1R10重组蛋白
  • 货号：
    CSB-MP836284HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PPP1R10
  • Uniprot No.：
    Q96QC0
  • 别名：
    CAT 53; CAT53; FB 19; FB19; FB19 protein; HLA-C associated transcript 53; MHC class I region proline rich protein CAT53; MHC class I region proline-rich protein CAT53; p99; Phosphatase 1 nuclear targeting subunit; Phosphatase nuclear targeting subunit; PNUTS; PP1 binding protein of 114 kDa; PP1 nuclear targeting subunit; PP1-binding protein of 114 kDa; PP1R10; PP1RA_HUMAN; ppp1r10; Protein FB19; Protein phosphatase 1 nuclear targeting subunit; Protein phosphatase 1 regulatory (inhibitor) subunit 10; Protein phosphatase 1 regulatory subunit 10; R111; Serine/threonine protein phosphatase 1 regulatory subunit 10; Serine/threonine-protein phosphatase 1 regulatory subunit 10
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.
  • 基因功能参考文献：
    1. The work demonstrates that PP1/PNUTS stabilizes chromatin-bound MYC in proliferating cells. PMID: 30158517
    2. A -31 G to A "hot zone" putative functional noncoding variant of PPP1R10 was found in an AML patient. It perturbs the binding activities of E2F1, E2F4, ZBTB33, and TBP. SRSF1 and PPP1R10 genes are interacting partners in a protein-protein interaction network. PMID: 29764005
    3. PNUTS is a bifunctional RNA encoding both PNUTS mRNA and lncRNA-PNUTS, each eliciting distinct biological functions. While PNUTS mRNA is ubiquitously expressed, lncRNA-PNUTS appears to be tightly regulated dependent on the status of hnRNP E1 and tumour context. PMID: 28825698
    4. Biophysical analysis of PNUTS suggests an extended transcription factor TFIIS-like fold. PMID: 27591855
    5. PNUTS was a valid target of miR-383 and was involved in the inhibition of gammaH2AX. PMID: 24462707
    6. PNUTS inhibits the PP1-mediated dephosphorylation of critical substrates, especially retinoblastoma protein, by blocking their binding sites on PP1. PMID: 24591642
    7. our studies reveal PNUTS as a novel PTEN regulator and a likely oncogene. PMID: 23117887
    8. PNUTS is identified as a new and integral component of the DNA damage response involved in DNA repair. PMID: 20890310
    9. stimulation of PP1 activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells PMID: 20372802
    10. PNUTS has a role in protein kinase A-regulated targeting of PP1 to specific RNA-associated complexes in the nucleus PMID: 12574161
    11. PNUTS, encoded by CAT 53 on 6p21.3, may have a role in the progression of AD. PMID: 15894402
    12. results illustrate an involvement of the PNUTS:PP1 holoenzyme in chromosome decondensation in vitro and argue that PNUTS functions as a PP1-targeting subunit in this process PMID: 15907195
    13. Findings suggest that PNUTS may play an important role in controlling cell death in response to cellular stresses such as hypoxia through the post-translational modification of p53 and MDM2. PMID: 17318220
    14. reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis PMID: 18360108
    15. the coordinated spatial and temporal regulation of LCP1 and PNUTS may be a novel mechanism to control the expression of genes that are critical for certain physiological and pathological processes. PMID: 19293638
    16. no evidence found of association between a CAT53 polymorphism and Alzheimer's Disease (AD), but found a significant negative association of the C282Y HFE mutation with AD PMID: 19429178

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 9284

    OMIM: 603771

    KEGG: hsa:5514

    STRING: 9606.ENSP00000365694

    UniGene: Hs.106019

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