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  4. Recombinant Human Serine/threonine-protein kinase ULK2 (ULK2), partial

Recombinant Human Serine/threonine-protein kinase ULK2 (ULK2), partial

  • 中文名称：
    人ULK2重组蛋白
  • 货号：
    CSB-YP811629HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ULK2重组蛋白
  • 货号：
    CSB-EP811629HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ULK2重组蛋白
  • 货号：
    CSB-EP811629HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ULK2重组蛋白
  • 货号：
    CSB-BP811629HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ULK2重组蛋白
  • 货号：
    CSB-MP811629HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ULK2
  • Uniprot No.：
    Q8IYT8
  • 别名：
    ATG1B; KIAA0623; Serine/threonine protein kinase ULK2; Serine/threonine-protein kinase ULK2; ULK2; ULK2_HUMAN; Unc 51 (C. elegans) like kinase 2; Unc 51 like autophagy activating kinase 2; Unc 51 like kinase 2; Unc-51-like kinase 2; Unc51.2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
  • 基因功能参考文献：
    1. MiRNA-26b may play a key role in cell growth and death of laryngeal carcinoma through ULK2 and the PTEN/AKT pathway. PMID: 28713931
    2. The serine/threonine kinase ULK2 binds to and phosphorylates CARMA2sh. PMID: 28230860
    3. Knockdown of ULK2 expression significantly induced autophagy, EMT, and cell migration in lung cancer cell line. PMID: 27062295
    4. miR-26b was down-regulated in LNCaP, DU145, C4-2 and PC-3 cells compared to the two normal prostate cells RWPE-1 and WPMY-1 except DU145 cells. This inversely correlates with ULK2 level in the same cell lines. PMID: 26920049
    5. Kapbeta2 interacts with ULK2 through ULK2's putative PY-NLS motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity. PMID: 26052940
    6. Glioblastoma and glioma cell lines had low levels of ULK2 transcripts. ULK2 promoter methylation and transcript levels showed significant negative correlation. PMID: 24923441
    7. First identification and naming of ULK2 as an ortholog of mouse ULK2. PMID: 12471243

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  • 亚细胞定位：
    Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
  • 数据库链接：

    HGNC: 13480

    OMIM: 608650

    KEGG: hsa:9706

    STRING: 9606.ENSP00000354877

    UniGene: Hs.168762

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