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  4. Recombinant Human Selenocysteine insertion sequence-binding protein 2 (SECISBP2), partial

Recombinant Human Selenocysteine insertion sequence-binding protein 2 (SECISBP2), partial

  • 中文名称：
    人SECISBP2重组蛋白
  • 货号：
    CSB-YP853506HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SECISBP2重组蛋白
  • 货号：
    CSB-EP853506HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SECISBP2重组蛋白
  • 货号：
    CSB-EP853506HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SECISBP2重组蛋白
  • 货号：
    CSB-BP853506HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SECISBP2重组蛋白
  • 货号：
    CSB-MP853506HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SECISBP2
  • Uniprot No.：
    Q96T21
  • 别名：
    DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11 89K14.1; SBP 2; SBP2; SEBP2_HUMAN; SECIS binding protein 2; SECIS-binding protein 2; SECISBP 2; SECISBP2; Selenocysteine insertion sequence binding protein 2; Selenocysteine insertion sequence-binding protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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SECISBP2 antibodies

靶点详情

  • 功能：
    Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
  • 基因功能参考文献：
    1. functions as a vital factor in selenoprotein translation and regulates the pro-oxidant/antioxidant balance in trophoblasts PMID: 28623977
    2. SBP2 interacts directly with four proteins of the SMN complex and the methylosome core proteins. PMID: 28115638
    3. SBP2 makes direct contacts with a discrete region of the human 28S rRNA. PMID: 24850884
    4. The patient showed typical symptoms of SBP2 deficiency, and novel compound heterozygous mutations were identified in SBP2 (p.M515fsX563/p.Q79X). PMID: 22247018
    5. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes. PMID: 22308032
    6. Describe subjects with compound heterozygous defects in the SECISBP2 gene. These individuals have reduced synthesis of most of the 25 known human selenoproteins, resulting in a complex phenotype. PMID: 21084748
    7. Results demonstrate that SECIS-binding protein 2 is required for protection against reactive oxygen species-induced cellular damage and cell survival. PMID: 19803747
    8. In addition to identifying key amino acids for SECIS recognition by SBP2, our findings led to the proposal that some of the recognition principles governing the 15.5 kD-U4 snRNA interaction must be similar in the SBP2-SECIS RNA complex PMID: 12403468
    9. Oxidative stress induces nuclear accumulation of SBP2 via oxidation of cysteine residues within a redox-sensitive cysteine-rich domain. PMID: 16782878
    10. Data suggest that SBP2 is a major determinant in dictating the hierarchy of selenoprotein synthesis via differential selenoprotein mRNA translation and sensitivity to nonsense-mediated decay. PMID: 17846120
    11. A report of a complex splicing pattern in the 5'-region of human SECISBP2, wherein at least eight splice variants encode five isoforms with varying N-terminal sequence. PMID: 19004874
    12. CUG-BP1 and HuR act as factors that bind to the SBP2 3' UTR, which suggests that TTR-RBPs play a role in the regulation of SBP2 PMID: 19106619
    13. Seleniuim is obviously not a limiting factor in the SBP2 deficient individuals when regular daily selenium intake is provided PMID: 19265499
    14. ca. 70% of the SBP2 sequence is disordered, whereas the RNA binding domain appears to be folded and functional. PMID: 19467292
    15. SBP2 gene mutation producing early arrest in synthesis of full-length molecule. Demonstration that SBP2 isoforms containing all functional domains could be synthesized from three downstream ATGs explains the relatively mild phenotype caused by this defect PMID: 19602558

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  • 相关疾病：
    Abnormal thyroid hormone metabolism (ATHYHM)
  • 亚细胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Mitochondrion.
  • 组织特异性：
    Expressed at high levels in testis.
  • 数据库链接：

    HGNC: 30972

    OMIM: 607693

    KEGG: hsa:79048

    STRING: 9606.ENSP00000364965

    UniGene: Hs.59804

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