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  4. Recombinant Human Scm-like with four MBT domains protein 1 (SFMBT1), partial

Recombinant Human Scm-like with four MBT domains protein 1 (SFMBT1), partial

  • 中文名称：
    人SFMBT1重组蛋白
  • 货号：
    CSB-YP883396HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SFMBT1重组蛋白
  • 货号：
    CSB-EP883396HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SFMBT1重组蛋白
  • 货号：
    CSB-EP883396HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SFMBT1重组蛋白
  • 货号：
    CSB-BP883396HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SFMBT1重组蛋白
  • 货号：
    CSB-MP883396HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SFMBT1
  • Uniprot No.：
    Q9UHJ3
  • 别名：
    DKFZp434L243; MGC93349; OTTMUSP00000030378; OTTMUSP00000030379; OTTMUSP00000030381; Renal ubiquitous protein 1; RU1; Scm like with four mbt domains 1; Scm like with four MBT domains protein 1; Scm related gene containing four mbt domains; Scm related gene product containing four mbt domains; Scm-like with four MBT domains protein 1; SFMBT; SFMBT 1; Sfmbt1; SMBT1_HUMAN; Smr
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.
  • 基因功能参考文献：
    1. copy number variation analysis identified deletions in SFMBT1 associated with fasting plasma glucose in a Han Chinese population PMID: 28789618
    2. The present study demonstrates that a copy number loss within intron 2 of the SFMBT1 gene may be a genetic risk factor for shunt-responsive definite iNPH. PMID: 27861535
    3. When bound to its gene targets, SFMBT1 recruits its associated proteins and causes chromatin compaction and transcriptional repression PMID: 23592795
    4. novel mechanisms accounting for SFMBT1-mediated transcription repression and revealed an essential role of Sfmbt1 in regulating MyoD-mediated transcriptional silencing PMID: 23349461
    5. Data identified IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes by gene based association scan and gene expression analysis. PMID: 22479346
    6. A segmental copy number loss of the SFMBT1 gene may be involved in the pathological process in some individuals with ventriculomegaly/idiopathic normal pressure hydrocephalus. PMID: 21325761
    7. The tandem MBT repeats form a functional structure required for biological activity of hSFMBT and predict similar properties for other MBT domain-containing proteins. PMID: 17599839

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in all cell lines and normal tissues tested, including the thymus.
  • 数据库链接：

    HGNC: 20255

    OMIM: 607319

    KEGG: hsa:51460

    STRING: 9606.ENSP00000350789

    UniGene: Hs.343679

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