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  4. Recombinant Human Sal-like protein 1 (SALL1), partial

Recombinant Human Sal-like protein 1 (SALL1), partial

  • 中文名称：
    人SALL1重组蛋白
  • 货号：
    CSB-YP882098HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SALL1重组蛋白
  • 货号：
    CSB-EP882098HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SALL1重组蛋白
  • 货号：
    CSB-EP882098HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SALL1重组蛋白
  • 货号：
    CSB-BP882098HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SALL1重组蛋白
  • 货号：
    CSB-MP882098HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SALL1
  • Uniprot No.：
    Q9NSC2
  • 别名：
    HSal1; Sal like protein 1; Sal-1; Sal-like protein 1; Sal1; SALL1; SALL1_HUMAN; Spalt-like transcription factor 1; TBS; Zinc finger protein 794; Zinc finger protein SALL1; Zinc finger protein Spalt-1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development.
  • 基因功能参考文献：
    1. SALL1 mutations might cause Townes-Brocks Syndrome. PMID: 29395072
    2. Inhibition of SALL1 correlates with reduced levels of CDH1, an important contributor to epithelial-to-mesenchymal transition. PMID: 24292671
    3. quantity and quality of SALL1 transcript are important for SALL1 function and determine phenotype, and mode of inheritance, of allelic SALL1-related disorders PMID: 23069192
    4. report on a family with features of TBS in whom a novel 149 kb deletion spanning the SALL1 gene was identified by high resolution cytogenetics SNP microarray PMID: 22308078
    5. novel role for Sall1 as a member of the transcriptional network that regulates stem cell pluripotency PMID: 21062744
    6. Sall1 induces angiogenesis by stimulating VEGF-A promoter activity. PMID: 19942929
    7. Mutation in Townes-Brocks syndrome. Product is a transcriptional repressor which interacts with TRF1/PIN2 and localizes to pericentromeric heterochromatin. PMID: 11751684
    8. binding of proteins SALL1, UBE2I and SUMO-1 PMID: 12200128
    9. sall1 enhances the canonical Wnt signaling by localizing to heterochromatin PMID: 15158448
    10. analysis of SALL1 mutations in Townes-Brocks syndrome PMID: 16088922
    11. Sall1 is essential for ureteric bud invasion, the initial key step for metanephros development PMID: 16221172
    12. there is a different contribution of SALL1 gene function to mouse and human embryonic development PMID: 16429401
    13. Data show that SALL1 contains two repression domains, one located at the extreme N-terminus of the protein and the other in the central region. PMID: 16443351
    14. SALL1 is a likely target gene for SIX1 during kidney development PMID: 16670092
    15. There is an enhancer element in the SALL1 gene. PMID: 17426652
    16. SALL1 gene, mutations of which result in the Townes-Brocks phenotype, is expressed in the developing kidney. PMID: 17910067
    17. SALL1 and GLI3 may have roles in limb malformation and are affected by nonsense-mediated decay PMID: 18000979
    18. analysis of one sporadic case of Townes-Brocks syndrome for SALL1 gene mutations and review of the literature [review] PMID: 18280297
    19. truncated SALL1 protein is expressed in cells derived from a TBS patient PMID: 18470945
    20. This case increases the demand to examine all children with Townes-Brocks Syndrome (TBS) for ophthalmic abnormalities. PMID: 19005989
    21. Familial transmission of Goldenhar syndrome is not due to mutations in SALL1. PMID: 19213029

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  • 相关疾病：
    Townes-Brocks syndrome 1 (TBS1)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Sal C2H2-type zinc-finger protein family
  • 组织特异性：
    Highest levels in kidney. Lower levels in adult brain (enriched in corpus callosum, lower expression in substantia nigra) and liver.
  • 数据库链接：

    HGNC: 10524

    OMIM: 107480

    KEGG: hsa:6299

    STRING: 9606.ENSP00000251020

    UniGene: Hs.135787

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