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  4. Recombinant Human SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1), partial

Recombinant Human SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1), partial

  • 中文名称：
    人SGIP1重组蛋白
  • 货号：
    CSB-YP887105HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SGIP1重组蛋白
  • 货号：
    CSB-EP887105HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SGIP1重组蛋白
  • 货号：
    CSB-EP887105HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SGIP1重组蛋白
  • 货号：
    CSB-BP887105HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SGIP1重组蛋白
  • 货号：
    CSB-MP887105HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SGIP1
  • Uniprot No.：
    Q9BQI5
  • 别名：
    SGIP1; SH3-containing GRB2-like protein 3-interacting protein 1; Endophilin-3-interacting protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
  • 基因功能参考文献：
    1. The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required. PMID: 28030933
    2. crystal structures of the SGIP1 mu homology domains in complex with peptides containing two DPF motifs, are reported. PMID: 26822536
    3. Our results show association between genetic variants in SGIP1 and fat mass. We provide evidence that variation in SGIP1 is a potentially important determinant of obesity-related traits in humans PMID: 21407171
    4. The earlier implicated single nucleotide polymorphisms located in SGIP1 gene showed no association with alcohol dependence or theta electroencephalogram power. PMID: 21317682
    5. SGIP1 and the signaling adaptor Reps1 interact with ITSN1 in vivo. PMID: 20946875
    6. SGIP1alpha plays an essential role in clathrin-mediated endocytosis by interacting with phospholipids and Eps15. PMID: 17626015

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  • 亚细胞定位：
    Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side.
  • 组织特异性：
    Specifically expressed in brain.
  • 数据库链接：

    HGNC: 25412

    OMIM: 611540

    KEGG: hsa:84251

    STRING: 9606.ENSP00000360076

    UniGene: Hs.132121

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