Recombinant Human S-methyl-5'-thioadenosine phosphorylase (MTAP)

1. melanoma risk alleles correlate with an allele-specific hyper-methylation and down-regulation of gene expression PMID: 27761950
2. The obtained data suggested a negative association between copy number variation of the MEAP genes and Atherothrombotic stroke. PMID: 28477716
3. High MTAP expression is associated with prostate cancer. PMID: 26910893
4. Results indicate complex rearrangements involving CDKN2A locus and frequent occurrence of fusion transcripts involving methylthioadenosine phosphorylase (MTAP) and ANRIL genes. PMID: 26909863
5. The SNP rs7023954 of methylthioadenosine phosphorylase co-dominantly expressed alleles revealed no difference in the conversion rate of 5'-methylthioadenosine to adenine and 5-methylthioribose-1-phosphate, indicating that this known enzymatic activity does not modulate the tumor suppressive function of methylthioadenosine phosphorylase. PMID: 27479139
6. Data demonstrate that MTAP deficiency leads to accumulation of MTA inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver. PMID: 26819315
7. methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. PMID: 27068473
8. MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors. PMID: 26751376
9. study to describe MTAP expression in a series of Pilocytic astrocytomas and relate it to the clinicopathological features of the patients; found MTAP expression is retained in Pilocytic astrocytomas and is not an outcome predictor for these tumors PMID: 26088413
10. MTAP deficiency was predictive of worse disease-specific survival and distant metastasis-free survival, suggesting its role in disease progression and as an independent prognostic biomarker of nasopharyngeal carcinoma PMID: 26656376
11. In the MTAP-deficient cases, the homozygous deletion of MTAP predicted adverse outcome. In MTAP-deficient cells, MTAP reexpression inhibited cell migration and invasion, proliferation and anchorage-independent colony formation and downregulated cyclin D1. PMID: 25426549
12. MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients. PMID: 24969958
13. MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB activation and apoptosis in hepatic stellate cells. PMID: 24324622
14. SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD. PMID: 23462334
15. Homozygous deletion of MTAP gene is associated with haploid lymphoblastic leukemia. PMID: 23508829
16. Authors report here that a high percentage of t-cell lymphoma lack the enzyme methylthioadenosine phosphorylase (MTAP). PMID: 23040436
17. MTAP gene might be involved in the etiology of myocardial infarction in Chinese Han ethnicity. PMID: 20302706
18. Letter: inactivation of MTAP expression seems to be an important step in the development and progression of malignant melanoma. of PMID: 23000879
19. Data indicate that a signature of seven biomarkers (Bax, Bcl-X, PTEN, COX-2, beta-Catenin, MTAP and CD20) was found to be an independent negative predictor for overall and recurrence-free survival in cutaneous malignant melanoma (MM). PMID: 22685558
20. A large negative heat capacity change of -600 cal/(mol K) upon inhibitor binding to MTAP is consistent with altered hydrophobic interactions and release of water. PMID: 21985704
21. Polymorphisms in nevus-associated genes MTAP is associated with invasive cutaneous melanoma. PMID: 21962134
22. The present study suggests that MTAP plays an important role in the regulation of gastric carcinogenesis. PMID: 21412930
23. Expression of MTAP is significantly higher in human colorectal cancer than in normal colorectal tissues. Demethylation of MTAP promoter may play an important role in up-regulating MTAP expression. PMID: 19622299
24. The expression of MTAP protein in non-small cell lung cancer tissue was significantly lower than that in paracarcinomous tissue and borderline lung tissue. PMID: 21342647
25. MTAP deficiency results in accumulation of 5'-deoxy-5'-methylthioadenosine, which is associated with increased tumorigenicity. PMID: 21356366
26. CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)), and MTAP are abundantly expressed in atherosclerotic lesions. PMID: 20637465
27. MTDIA antitumor activity in xenografts supports MTAP as a target for lung cancer therapy. PMID: 21135097
28. Single nucleotide polymorphism in MTAP gene is associated with nevi. PMID: 20574843
29. Detection of CDKN2A-MTAP co-deletion in peritoneal mesotheliomas can help identify those patients who may have an unfavorable outcome PMID: 20081810
30. MTAP homozygous deletion, the predominant mechanism to deplete protein expression, is present in 17% of gastrointestinal stromal tumors PMID: 19887491
31. Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line. PMID: 12438261
32. Results suggest an important role of methylthioadenosine phosphorylase inactivation in the development of melanomas. PMID: 12875987
33. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites PMID: 14506228
34. MTAP is not expressed in normal human colonic epithelium but is strongly upregulated in colon carcinoma. PMID: 15492751
35. epigenetic mechanisms, involving DNA methylation and histone deacetylation, may play a role in the silencing of MTAP gene expression in hepatocarcinoma PMID: 15511635
36. MTAP activity is frequently lost, and ODC activity is frequently elevated in both pancreatic adenocarcinoma and neuroendocrine tumors PMID: 15534104
37. MTAP expression is lost in approximately 30% of infiltrating pancreatic cancers and in a lower percentage of other periampullary neoplasms; loss is a result of homozygous deletions encompassing both the MTAP and p16INK4A/CDKN2A genes PMID: 15662124
38. Results demonstrated concordant loss of MTAP and p16 protein expression in pancreatic intraepithelial neoplasia. PMID: 15832197
39. MTAP inactivation is associated with hepatocellular carcinoma development and invasiveness PMID: 16081515
40. Selective loss at the 3' end of MTAP was observed in head and neck squamous cell carcinoma cell line UMSCC-11A. PMID: 16618910
41. The frequency of Methylthioadenosine phosphorylase (MTAP) deletions in conventional, grade II chondrosarcomas by fluorescence in situ hybridization (FISH) analysis was investigated. PMID: 16631464
42. Methylthioadenosine phosphorylase (MTAP) gene deletion and lack of protein expression are associated with poor prognosis in mantle cell lymphoma. PMID: 16778103
43. Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver PMID: 18237276
44. analysis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma PMID: 18555557
45. This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of myocardial infarction in Chinese. PMID: 19272367
46. The G allele of rs10118757 was associated with an increased risk of stroke in Han Chinese even after controlling for confounding factors. The GA+GG genotype was associated with the increased risk of an undetermined subtype of ischemic stroke. PMID: 19427650

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HGNC: 7413

OMIM: 112250

KEGG: hsa:4507

STRING: 9606.ENSP00000369519

UniGene: Hs.193268