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  4. Recombinant Human Ribosome-binding protein 1 (RRBP1), partial

Recombinant Human Ribosome-binding protein 1 (RRBP1), partial

  • 中文名称：
    人RRBP1重组蛋白
  • 货号：
    CSB-YP879068HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RRBP1重组蛋白
  • 货号：
    CSB-EP879068HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RRBP1重组蛋白
  • 货号：
    CSB-EP879068HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RRBP1重组蛋白
  • 货号：
    CSB-BP879068HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RRBP1重组蛋白
  • 货号：
    CSB-MP879068HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RRBP1
  • Uniprot No.：
    Q9P2E9
  • 别名：
    180 kDa ribosome receptor homolog; DKFZp586A1420; ES/130; ES/130 related protein; ES/130-related protein; ES130; FLJ36146; hES; KIAA1398; MGC157720; MGC157721; Ribosome binding protein 1; Ribosome binding protein 1 homolog 180kDa; Ribosome binding protein 1 homolog; Ribosome receptor protein; Ribosome-binding protein 1; RRBP 1; Rrbp1; RRBP1_HUMAN; RRP
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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RRBP1 antibodies

靶点详情

  • 功能：
    Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.
  • 基因功能参考文献：
    1. High RRBP1 expression facilitates colorectal cancer progression and predicts an unfavourable post-operative prognosis. PMID: 26196185
    2. Data indicate that p180 is required for the efficient targeting of placental alkaline phosphatase (ALPP) mRNA to the endoplasmic reticulum (ER). PMID: 24019514
    3. RRBP1 could alleviate ER stress and help cancer cell survive PMID: 23318453
    4. p180 is concentrated in ER sheets by interacting with polysomes and may play a role in ER morphology. PMID: 21111237
    5. p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum. PMID: 22679391
    6. A novel function of p180-abundant endoplasmic reticulum on the trans-Golgi network expansion, both of which are highly developed in various professional secretory cells. PMID: 19932094
    7. p180 plays crucial roles in enhancing collagen biosynthesis at the entry site of the secretory compartments by a novel mechanism that mainly involves facilitating ribosome association on the ER. PMID: 20647306
    8. Results identify the ribosome receptor, p180, as a binding partner of the kinesin heavy chain isoform KIF5B. PMID: 15184079
    9. These data suggest that p180 mediates interactions between the endoplasmic reticulum and microtubules mainly through the novel microtubule-binding and -bundling domain MTB-1. PMID: 17634287
    10. over-expression of p180R failed to increase secretory pathway proteins calnexin, SEC61beta, and calreticulin, or ribosome biogenesis PMID: 18083570
    11. results obtained demonstrate that p180 is both necessary & sufficient to induce a secretory phenotype in mammalian cells; findings support a central role for p180 in the terminal differentiation of secretory cells & tissues PMID: 19037105
    12. the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type III membrane protein.
  • 数据库链接：

    HGNC: 10448

    OMIM: 601418

    KEGG: hsa:6238

    STRING: 9606.ENSP00000354045

    UniGene: Hs.472213

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